[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

ED Mock, B Gagestein, M van der Stelt - Progress in Lipid Research, 2023 - Elsevier
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Mechanisms of adhesion G protein–coupled receptor activation

A Vizurraga, R Adhikari, J Yeung, M Yu… - Journal of Biological …, 2020 - ASBMB
Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

X Qu, N Qiu, M Wang, B Zhang, J Du, Z Zhong, W Xu… - Nature, 2022 - nature.com
Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological
processes such as immune responses, organ development, cellular communication …

Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology

T Lala, RA Hall - Physiological Reviews, 2022 - journals.physiology.org
Adhesion G protein-coupled receptors: structure, signaling, physiology, and
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …

The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond

M Murakami - Pharmacology & therapeutics, 2023 - Elsevier
Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling

X Zhu, Y Qian, X Li, Z Xu, R Xia, N Wang… - Nature …, 2022 - nature.com
Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and
attractive targets for various diseases. aGPCRs are also known to be capable of self …

A guide to adhesion GPCR research

I Liebscher, O Cevheroğlu, CC Hsiao… - The FEBS …, 2022 - Wiley Online Library
Adhesion G protein‐coupled receptors (aGPCRs) are a class of structurally and functionally
highly intriguing cell surface receptors with essential functions in health and disease. Thus …

Molecular and signaling mechanisms for docosahexaenoic acid-derived neurodevelopment and neuroprotection

HY Kim, BX Huang, AA Spector - International Journal of Molecular …, 2022 - mdpi.com
The neurodevelopmental and neuroprotective actions of docosahexaenoic acid (DHA) are
mediated by mechanisms involving membrane-and metabolite-related signal transduction. A …

Progress report on new antiepileptic drugs: A summary of the Fifteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XV). I. Drugs in preclinical …

M Bialer, SI Johannessen, MJ Koepp, RH Levy… - …, 2020 - Wiley Online Library
Abstract Since 1992, the Eilat Conferences have provided a forum for all stakeholders in the
epilepsy community to appraise the latest data on new antiepileptic drugs and emergency …

Segregated functions of two cytosolic phospholipase A2 isoforms (cPLA2α and cPLA2ε) in lipid mediator generation

M Murakami, R Takamiya, Y Miki, N Sugimoto… - Biochemical …, 2022 - Elsevier
Among the phospholipase A 2 (PLA 2) superfamily, group IVA cytosolic PLA 2 (cPLA 2 α) is
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …