An overview of epithelial growth factor receptor (EGFR) inhibitors in cancer therapy

KS Alharbi, MAJ Shaikh, O Afzal, ASA Altamimi… - Chemico-Biological …, 2022 - Elsevier
Epithelial growth factor receptor (EGFR), a transmembrane receptor on the cell surface,
carries extracellular messages into the cell and alters the activity of the nucleus through …

Therapeutically targeting cancers that overexpress FOXC1: A transcriptional driver of cell plasticity, partial EMT, and cancer metastasis

T Ray, T Ryusaki, PS Ray - Frontiers in Oncology, 2021 - frontiersin.org
Metastasis accounts for more than 90% of cancer related mortality, thus the most pressing
need in the field of oncology today is the ability to accurately predict future onset of …

Choline kinase alpha is a novel transcriptional target of the Brg1 in hepatocyte: implication in liver regeneration

M Kong, W Dong, H Xu, Z Fan, X Miao… - Frontiers in Cell and …, 2021 - frontiersin.org
Liver regeneration is a key compensatory process in response to liver injury serving to
contain damages and to rescue liver functions. Hepatocytes, having temporarily exited the …

Saffron, its active components, and their association with DNA and histone modification: A narrative review of current knowledge

M Rashid, H Brim, H Ashktorab - Nutrients, 2022 - mdpi.com
Intensive screening for better and safer medications to treat diseases such as cancer and
inflammatory diseases continue, and some phytochemicals have been discovered to have …

Calcineurin/NFATc1 pathway represses cellular cytotoxicity by modulating histone H3 expression

Y Sato, M Habara, S Hanaki, J Sharif, H Tomiyasu… - Scientific Reports, 2024 - nature.com
Excess amounts of histones in the cell induce mitotic chromosome loss and genomic
instability, and are therefore detrimental to cell survival. In yeast, excess histones are …

Bioinformatics study revealed significance of exosome transcriptome in hepatocellular carcinoma diagnosis

ZH Wu, C Li, YJ Zhang, R Lin - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Background: Hepatocellular carcinoma (HCC) is one of the fifty most common cancers
globally, having a high mortality rate being the second most common cause of cancer …

A KDM4-DBC1-SIRT1 axis contributes to TGF-b induced mesenchymal transition of intestinal epithelial cells

B Chen, W Dong, T Shao, X Miao, Y Guo… - Frontiers in Cell and …, 2021 - frontiersin.org
Intestinal fibrosis is one of the common pathophysiological processes in inflammatory bowel
diseases (IBDs). Previously it has been demonstrated that epithelial-mesenchymal transition …

[HTML][HTML] Identifying Key Genes Involved in Axillary Lymph Node Metastasis in Breast Cancer Using Advanced RNA-Seq Analysis: A Methodological Approach with …

M Rezapour, R Wesolowski, MN Gurcan - International Journal of …, 2024 - mdpi.com
Our study aims to address the methodological challenges frequently encountered in RNA-
Seq data analysis within cancer studies. Specifically, it enhances the identification of key …

HES5-mediated repression of LIGHT transcription may contribute to apoptosis in hepatocytes

X Miao, Y Guo, S Zeng, X Liu, X Teng, L Li… - Cell Death Discovery, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is prototypical form of metabolic syndrome and
has become a global pandemic. Hepatocytes undergo apoptosis in the pathogenesis of …

[HTML][HTML] A Systematic Exploration of Key Candidate Genes and Pathways in the Biogenesis of Human Gastric Cancer: A Comprehensive Bioinformatics Investigation

S Hannan, I Hami, RK Dey… - Journal of Translational …, 2024 - xiahepublishing.com
Methods This objective was achieved through the analysis of differentially expressed genes
(DEGs) from three datasets obtained from the Gene Expression Omnibus (GEO). By doing …