There have been significant advances in our understanding of mononuclear nonheme iron
oxygenases since our 1996 Chemical Reviews article, 1 promoted in large part by the many …

Fe (II)/α-ketoglutarate (αKG)-dependent hydroxylases catalyze an amazing diversity of
reactions that result in protein side-chain modifications, repair of alkylated DNA/RNA …

High-valent non-heme iron–oxo intermediates have been proposed for decades as the key
intermediates in numerous biological oxidation reactions. In the past three years, the first …

Mononuclear non-heme ferrous iron dependent oxygenases and oxidases constitute an
extended enzyme family that catalyze a wide range of oxidation reactions. The largest …

Covering: up to May 2012The β-lactam antibiotics and related β-lactamase inhibitors are
amongst the most important small molecules in clinical use. Most, but not all, β-lactams …

The mechanisms of four enzymes that initiate oxidation of their substrates by using mid-
valent metal–superoxo intermediates, rather than the more frequently described high-valent …

Resistance to β‐lactam antibacterials is commonly associated with the production of the
serine β‐lactamases (SBLs) and/or metallo‐β‐lactamases (MBLs). Although clinically useful …

A growing number of non-heme-iron oxygenases and oxidases catalyze reactions for which
the well-established mechanistic paradigm involving a single C–H-bond-cleaving …

The molecular structure of the previously reported species “[Fe (bd t bpza) Cl]” has been
revealed by X-ray structure determination to be a ferrous dimer [Fe (bd t bpza) Cl] 2 (2c)[bd t …

To highlight the role of the protein in metal enzyme catalysis, we optimize ONIOM QM: MM
transition states and intermediates for the full reaction of the nonheme iron enzyme …