Interplay between MAPK/ERK signaling pathway and MicroRNAs: A crucial mechanism regulating cancer cell metabolism and tumor progression

ER Asl, M Amini, S Najafi, B Mansoori, A Mokhtarzadeh… - Life sciences, 2021 - Elsevier
Mitogen-activated protein kinase (MAPK) signal transduction, as a highly conserved
signaling pathway, is reported to be involved in various biological events, including …

microRNA-382 as a tumor suppressor? Roles in tumorigenesis and clinical significance

M Fattahi, S Shahrabi, F Saadatpour, D Rezaee… - International journal of …, 2023 - Elsevier
MicroRNAs (miRNAs) are small single-stranded RNAs belonging to a class of non-coding
RNAs with an average length of 18–22 nucleotides. Although not able to encode any …

[HTML][HTML] Cancer‑associated fibroblast‑derived exosomal miR‑382‑5p promotes the migration and invasion of oral squamous cell carcinoma

LP Sun, K Xu, J Cui, DY Yuan, B Zou… - Oncology …, 2019 - spandidos-publications.com
Oral squamous cell carcinoma (OSCC), with high potential for metastasis, is the most
common malignant tumor of the head and neck. Cancer‑associated fibroblasts (CAFs) are …

[HTML][HTML] Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the …

I Stevic, V Müller, K Weber, PA Fasching, T Karn… - BMC medicine, 2018 - Springer
Background The focus of this study is to identify particular microRNA (miRNA) signatures in
exosomes derived from plasma of 435 human epidermal growth factor receptor 2 (HER2) …

[HTML][HTML] Epigenetic regulation of triple negative breast cancer (TNBC) by TGF-β signaling

R Vishnubalaji, NM Alajez - Scientific Reports, 2021 - nature.com
TGFβ signaling plays crucial role during development and cancer, however the role for
TGFβ signaling in regulating the noncoding part of the human genome in triple negative …

[HTML][HTML] Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells

A Lewinska, J Adamczyk-Grochala, A Deregowska… - Theranostics, 2017 - ncbi.nlm.nih.gov
Cancer cells are characterized by genetic and epigenetic alterations and phytochemicals,
epigenetic modulators, are considered as promising candidates for epigenetic therapy of …

[HTML][HTML] Targeting KRAS in Cancer: Promising Therapeutic Strategies

LM Mustachio, A Chelariu-Raicu, L Szekvolgyi… - Cancers, 2021 - mdpi.com
Simple Summary Since the Kirsten rat sarcoma viral oncogene homolog (KRAS) is mutated
in about 25% of all human cancers and is at the center of pathways involved in …

[HTML][HTML] Long non-coding RNA GAPLINC promotes tumor-like biologic behaviors of fibroblast-like synoviocytes as microRNA sponging in rheumatoid arthritis patients

BY Mo, XH Guo, MR Yang, F Liu, X Bi, Y Liu… - Frontiers in …, 2018 - frontiersin.org
Rapidly accumulating evidence has now suggested that the long non-coding RNAs
(LncRNAs), a large and diverse class of non-coding transcribed RNA molecules with diverse …

[HTML][HTML] RAS as supporting actor in breast cancer

M Galiè - Frontiers in oncology, 2019 - frontiersin.org
Oncogenic activation of RAS isoforms leads tumor initiation and progression in many types
of cancers and is gaining increasing interest as target for novel therapeutic strategies. In …

Circ_0000190 sponges miR-382-5p to suppress cell proliferation and motility and promote cell death by targeting ZNRF3 in gastric cancer

M Jiang, R Mo, C Liu, H Wu - The Journal of Biochemistry, 2022 - academic.oup.com
This study was to explore the role of circRNA_0000190 (circ_0000190) in gastric cancer
(GC) progression. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) …