The transition from normal to chronic pain is believed to involve alterations in several brain
areas that participate in the perception of pain. These plastic changes are then responsible …

The insular cortex is one of the brain regions that show consistent abnormalities in both
structural and functional neuroimaging studies of schizophrenia. In healthy individuals, the …

Anxiety is an unpleasant physiological state in which an overreaction to a situation occurs. It
has been suggested that different brain regions are involved in the modulation and …

Recent insights have demonstrated a central role for dopaminergic neurotransmission in
modulating pain perception and natural analgesia within supraspinal regions, including the …

Dopamine plays an important role in fear and anxiety modulating a cortical brake that the
medial prefrontal cortex exerts on the anxiogenic output of the amygdala and have an …

Converging preclinical, and human epidemiological, neuroimaging, and genetic evidence
suggests a central role for dopamine neurotransmission in modulating pain perception and …

Neuropathic pain has been described as the “most terrible of all tortures which a nerve
wound may inflict” and arises as a consequence of nerve injury either of the peripheral or …

Neurons in the insular cortex are activated by acute and chronic pain, and inhibition of
neuronal activity in the insular cortex has analgesic effects. We found that in a mouse model …

Pain is a complex experience encompassing sensory-discriminative, affective-motivational
and cognitiv e-emotional components mediated by different mechanisms. Contrary to the …

Pain and sensory abnormalities are present in a large proportion of Parkinson disease (PD)
patients and have a significant negative impact in quality of life. It remains undetermined …