Concerns about the safety of anesthetic agents in children arose after animal studies
revealed disruptions in neurodevelopment after exposure to commonly used anesthetic …

Background: Children undergoing complex cardiac surgery are exposed to substantial
cumulative doses of sedative medications and volatile anesthetics and are more frequently …

Background Melatonin is known to have protective effects in aging, neurodegenerative
disorders and mitochondria-related diseases, while there is a poor understanding of the …

Hypoxic–ischemic brain injury is an important cause of neonatal neurological deficits. Our
previous study demonstrated that dexmedetomidine (Dex) provided neuroprotection against …

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric
disorders that affects children and even continues into adulthood. Dexmedetomidine (DEX) …

Propofol is neurotoxic to trigger neuronal pyroptosis and dexmedetomidine possesses the
ability to suppress proptosis. This study expounded on the protective functions of …

Background While a number of anesthetics has been shown potentially associated with
neurotoxicity in the developing brain, dexmedetomidine, a drug that was rather recently …

Anesthetics have been shown to cause cytotoxicity, cell death, affect neuronal growth and
connectivity in animal models; however, their effects on learning and memory remain to be …

Background Dexmedetomidine is known for its selective action on α2-adrenoceptor sites
and is recognized for its neuroprotective capabilities. It can improve postoperative cognitive …

Introduction Dexmedetomidine is the sedative agent administered in combination with
remifentanil and low dose of sevoflurane in the interventional arm of the ongoing TREX trial …