[HTML][HTML] Tumor-intrinsic PD-L1 signaling in cancer initiation, development and treatment: beyond immune evasion
P Dong, Y Xiong, J Yue, SJB Hanley, H Watari - Frontiers in oncology, 2018 - frontiersin.org
Although the role of PD-L1 in suppressing the anti-tumor immune response is extensively
documented, recent discoveries indicate a distinct tumor-intrinsic role for PD-L1 in …
documented, recent discoveries indicate a distinct tumor-intrinsic role for PD-L1 in …
[HTML][HTML] Biology of invasive mucinous adenocarcinoma of the lung
Invasive mucinous adenocarcinoma (IMA) is a unique histologic subtype of lung
adenocarcinoma. Recent studies document distinctive genetic alterations (eg, NRG1 …
adenocarcinoma. Recent studies document distinctive genetic alterations (eg, NRG1 …
Localization of secretory mucins MUC5AC and MUC5B in normal/healthy human airways
Rationale: MUC5AC and MUC5B are the predominant gel-forming mucins in the mucus
layer of human airways. Each mucin has distinct functions and site-specific expression …
layer of human airways. Each mucin has distinct functions and site-specific expression …
NRF2 activation promotes aggressive lung cancer and associates with poor clinical outcomes
Purpose: Stabilization of the transcription factor NRF2 through genomic alterations in KEAP1
and NFE2L2 occurs in a quarter of patients with lung adenocarcinoma and a third of patients …
and NFE2L2 occurs in a quarter of patients with lung adenocarcinoma and a third of patients …
[HTML][HTML] Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma
T Ebisudani, J Hamamoto, K Togasaki, A Mitsuishi… - Cell Reports, 2023 - cell.com
Human lung cancer is a constellation of tumors with various histological and molecular
properties. To build a preclinical platform that covers this broad disease spectrum, we …
properties. To build a preclinical platform that covers this broad disease spectrum, we …
[HTML][HTML] Cryobiopsy: a breakthrough strategy for clinical utilization of lung cancer organoids
One major challenge associated with lung cancer organoids (LCOs) is their predominant
derivation from surgical specimens of patients with early-stage lung cancer. However …
derivation from surgical specimens of patients with early-stage lung cancer. However …
An LKB1–SIK axis suppresses lung tumor growth and controls differentiation
The kinase LKB1 is a critical tumor suppressor in sporadic and familial human cancers, yet
the mechanisms by which it suppresses tumor growth remain poorly understood. To …
the mechanisms by which it suppresses tumor growth remain poorly understood. To …
[HTML][HTML] Transcription factor NKX2–1 drives serine and glycine synthesis addiction in cancer
E Heylen, P Verstraete, L Van Aerschot… - British journal of …, 2023 - nature.com
Background One-third of cancers activate endogenous synthesis of serine/glycine, and can
become addicted to this pathway to sustain proliferation and survival. Mechanisms driving …
become addicted to this pathway to sustain proliferation and survival. Mechanisms driving …
[HTML][HTML] FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer
SA Camolotto, S Pattabiraman, TL Mosbruger, A Jones… - Elife, 2018 - elifesciences.org
Changes in cancer cell identity can alter malignant potential and therapeutic response. Loss
of the pulmonary lineage specifier NKX2-1 augments the growth of KRAS-driven lung …
of the pulmonary lineage specifier NKX2-1 augments the growth of KRAS-driven lung …
XBP1S regulates MUC5B in a promoter variant–dependent pathway in idiopathic pulmonary fibrosis airway epithelia
Rationale: The goal was to connect elements of idiopathic pulmonary fibrosis (IPF)
pathogenesis, including chronic endoplasmic reticulum stress in respiratory epithelia …
pathogenesis, including chronic endoplasmic reticulum stress in respiratory epithelia …