[HTML][HTML] Mathematical modeling of regulatory networks of intracellular processes–Aims and selected methods
M Kardynska, D Kogut, M Pacholczyk… - Computational and …, 2023 - Elsevier
Regulatory networks structure and signaling pathways dynamics are uncovered in time-and
resource consuming experimental work. However, it is increasingly supported by modeling …
resource consuming experimental work. However, it is increasingly supported by modeling …
The population context is a driver of the heterogeneous response of epithelial cells to interferons
C Metz-Zumaran, ZM Uckeley, P Doldan… - Molecular Systems …, 2024 - embopress.org
Isogenic cells respond in a heterogeneous manner to interferon. Using a micropatterning
approach combined with high-content imaging and spatial analyses, we characterized how …
approach combined with high-content imaging and spatial analyses, we characterized how …
Development of a highly sensitive platform for protein–protein interaction detection and regulation of T cell function
We developed a highly sensitive assay for detecting protein–protein interaction using
chimeric receptors comprising two molecules of interest in the extracellular domain and …
chimeric receptors comprising two molecules of interest in the extracellular domain and …
Tumour cells can escape antiproliferative pressure by interferon-β through immunoediting of interferon receptor expression
F Hiebinger, A Kudulyte, H Chi… - Cancer cell …, 2023 - Springer
Type I interferons (IFNs) play a central role not only in innate immunity against viral infection,
but also in the antitumour response, eg through a direct impact on cell proliferation …
but also in the antitumour response, eg through a direct impact on cell proliferation …
Antagonism between viral infection and innate immunity at the single-cell level
F Grabowski, M Kochańczyk, Z Korwek… - PLoS …, 2023 - journals.plos.org
When infected with a virus, cells may secrete interferons (IFNs) that prompt nearby cells to
prepare for upcoming infection. Reciprocally, viral proteins often interfere with IFN synthesis …
prepare for upcoming infection. Reciprocally, viral proteins often interfere with IFN synthesis …
血清4 型禽腺病毒感染LMH 细胞后干扰素刺激基因在转录水平表达量的动态变化
万丽军， 王盛， 谢芝勋， 任红玉， 谢丽基， 范晴， 罗思思… - 中国畜牧兽医, 2024 - chvm.net
[目的] 了解鸡肝癌细胞(LMH) 感染血清4 型禽腺病毒(FAdV-4) 后干扰素(IFN)
和干扰素刺激基因(ISGs) 的表达量变化, 为研究FAdV-4 与ISGs 的相互作用提供参考依据.[方法] …
和干扰素刺激基因(ISGs) 的表达量变化, 为研究FAdV-4 与ISGs 的相互作用提供参考依据.[方法] …
Population context drives cell-to-cell variability in interferon response in epithelial cells
C Metz-Zumaran, P Doldan, F Muraca, Y Keser… - bioRxiv, 2023 - biorxiv.org
Isogenic cells respond in a heterogeneous manner to interferon. Using a micropatterning
approach combined with high-content imaging and spatial analyses, we characterized how …
approach combined with high-content imaging and spatial analyses, we characterized how …
The impact of the population context on virus infection, IFN response, and homeostatic immune signaling in mucosal epithelial cells
C Metz Zumaran - 2025 - archiv.ub.uni-heidelberg.de
Mucosal tissues act as a protective barrier in constant contact with microbiota. Epithelial
cells on these surfaces must mount an effective immune response for protection from …
cells on these surfaces must mount an effective immune response for protection from …