Cancer is driven by multiple types of genetic alterations, which range in size from point
mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome …

The ubiquitin-proteasome system (UPS) is involved in multiple aspects of cellular processes,
such as cell cycle progression, cellular differentiation, and survival (Davis RJ et al., Cancer …

Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent
polymorphism in short repetitive DNA sequences and single nucleotide substitution, as …

The number of molecularly stratified treatment options available to patients with colorectal
cancer (CRC) is increasing, with a parallel rise in the use of biomarkers to guide …

Background Improved markers of prognosis are needed to stratify patients with early-stage
colorectal cancer to refine selection of adjuvant therapy. The aim of the present study was to …

Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …

Long non-coding RNAs (lncRNAs) are an important novel class of non-coding RNAs having
lengths of 200 nucleotides and low expression. The HOX Transcript Antisense Intergenic …

Chromosome instability (CIN) is gaining increasing interest as a central process in cancer.
CIN, either past or present, is indicated whenever tumour cells harbour an abnormal quantity …

Background Somatic mutations in the phosphatidylinositol-4, 5-bisphosphate 3-kinase/AKT
pathway play a vital role in carcinogenesis. Approximately 15%–20% of colorectal cancers …

Background: Evasion of immune surveillance and suppression of the immune system are
important hallmarks of tumour development in colon cancer. The goal of this study was to …