Critically ill patients are at high risk for development of life-threatening infection leading to
sepsis and multiple organ failure. Adequate antimicrobial therapy is pivotal for optimizing the …

Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …

Context Infection is a major cause of morbidity and mortality in intensive care units (ICUs)
worldwide. However, relatively little information is available about the global epidemiology …

ContextIn the intensive care unit (ICU), delirium is a common yet underdiagnosed form of
organ dysfunction, and its contribution to patient outcomes is unclear. ObjectiveTo determine …

Objective: To determine recent trends in rates of hospitalization, mortality, and hospital case
fatality for severe sepsis in the United States. Design: Trend analysis for the period from …

Despite advances in critical care medicine, infection remains a significant problem that
continues to be complicated with the challenge of antibiotic resistance …

Objective: To extract from the biomedical literature the reported effects of acute
hyperglycemia on the major components of the innate immune system and to describe the …

Background Sepsis is a common, expensive and frequently fatal condition. There is an
urgent need for developing new therapies to further reduce severe sepsis‐induced mortality …

Objective: To assess the impact of an algorithm defining resuscitation according to early
goal-directed therapy, glycemic control, administration of stress doses of hydrocortisone …

Infection is often difficult to recognize in critically ill patients because of the marked
coexisting inflammatory process. Lack of early recognition prevents timely resuscitation and …