The polarized nature of epithelial cells is manifested by the nonrandom partitioning of
organelles within the cells, the concentration of intercellular junctions at one pole, and the …

Desmosomes are prominent adhesion sites that are tightly associated with the cytoplasmic
intermediate filament cytoskeleton providing mechanical stability in epithelia and also in …

We have previously shown that aPKC interacts with cell polarity proteins PAR-3 and PAR-6
and plays an indispensable role in cell polarization in the C. elegans one-cell embryo as …

Invertebrate animals have been used as medicinals for 4,000 years and have served as
models for research and teaching since the late 1800s. Interest in invertebrate models has …

Epithelial tubes are basic building blocks of complex organs, but their architectural
requirements are not well understood. Here we show that erm-1 is a unique C. elegans …

Members of the ezrin-radixin-moesin (ERM) family of proteins have been found to serve as
linkers between membrane proteins and the F-actin cytoskeleton in many organisms. We …

Understanding transdifferentiation—the conversion of one differentiated cell type into
another—is important from both basic science and clinical perspectives. In Caenorhabditis …

Invertebrate diversity and architecture is immense. This is achieved by the organization and
function of four tissue types found in most metazoan phyla—epithelial, connective, muscle …

Cell rearrangements are crucial during development. In this study, we use C. elegans
gastrulation as a simple model to investigate the mechanisms of cell positioning. During C …

We wish to understand how organ-specific structures assemble during embryonic
development. In the present paper, we consider what determines the subapical position of …