Key Clinical Points Lynch Syndrome–Associated Colorectal Cancer The Lynch syndrome is
the most common inherited syndrome associated with colorectal cancer, accounting for 3 …

Lynch syndrome is a cancer-predisposing syndrome inherited in an autosomal-dominant
manner, wherein colon cancer and endometrial cancer develop frequently in the family, it …

Background Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA
mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States …

Lynch syndrome, an autosomal dominant inherited disorder, is caused by inactivating
mutations involving DNA mismatch repair (MMR) genes. This leads to profound genetic …

Methods In this retrospective case-case study, patients were prospectively enrolled from
2015 to 2018. We collected clinical features (age, sex, time from symptom onset to …

Aims The presence of a BRAF mutation is a strong marker for poor prognosis of colorectal
carcinoma (CRC), and can be used as evidence of a sporadic mechanism of mismatch …

Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome,
with a prevalence of 1 in 279 (0.36%) individuals in the general population. 1 Previously …

Lynch syndrome accounts for roughly 1 of every 35 patients with colorectal carcinoma,
making it the most common hereditary form of colorectal carcinoma. Identifying patients at …

To determine the correlation between BRAF genotype and MLH1 promoter methylation in a
screening program for Lynch syndrome (LS), a universal screening program for LS was …

At least 15% of colorectal cancers diagnosed in the United States are deficient in mismatch
repair mechanisms. Most of these are sporadic, but approximately 3% of colorectal cancers …