This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core
of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Epithelial and endothelial monolayers are multicellular sheets that form barriers between the
'outside'and 'inside'of tissues. Cell-cell junctions, made by adherens junctions, tight junctions …

Physical forces regulate numerous biological processes during development, physiology,
and pathology. Forces between the external environment and intracellular actin cytoskeleton …

The endoplasmic reticulum (ER) forms a dynamic network that contacts other cellular
membranes to regulate stress responses, calcium signalling and lipid transfer. Here, using …

Mechanical cues are crucial for survival, adaptation, and normal homeostasis in virtually
every cell type. The transduction of mechanical messages into intracellular biochemical …

The development of adhesive connections between cells was critical for the evolution of
multicellularity and for organizing cells into complex organs with discrete compartments …

Desmosomes are intercellular adhesion complexes that connect the intermediate filament
cytoskeletons of neighboring cells, and are essential for the mechanical integrity of …

The desmosome is a cell–cell adhesive junction that provides integrity and mechanical
resistance to tissues through its attachment to the intermediate filament cytoskeleton …