Cerebral perfusion modelling is a promising tool to predict the impact of acute ischaemic
stroke treatments on the spatial distribution of cerebral blood flow (CBF) in the human brain …

The cerebral vasculature plays a critical role in the transport of oxygen and other nutrients to
brain tissue. However, the size, complexity, and paucity of detailed anatomical information of …

Until recently, scientists thought that waste was cleared from the central nervous system
primarily by diffusion, with waste slowly moving from the brain tissue toward the blood …

Objective Haemorrhagic transformation (HT) is one of the most common complications after
ischaemic stroke. HT can be the result of stroke progression or a complication of reperfusion …

In ischaemic stroke, a large reduction in blood supply can lead to the breakdown of the
blood-brain barrier and to cerebral oedema after reperfusion therapy. The resulting fluid …

Poor outcome following traumatic acute subdural hematoma (ASDH) is associated with the
severity of the primary injury and secondary injury including cerebral edema and ischemia …

Whole brain models are a valuable tool to gain a better understanding of cerebral blood flow
and metabolism. Recent work has developed multi-compartment models of blood flow and …

Microcirculation is a key area of interest within the realms of biology and medicine. As a vital
discipline, microcirculatory biology forms a significant part of established medical fields like …

The cerebral microcirculation is a highly complex interconnected network of vessels that
cover a wide range of length scales and respond over a wide range of time scales. It plays a …

Over the past few decades, osmotherapy has commonly been employed to reduce
intracranial pressure in post-stroke oedema. However, evaluating the effectiveness of …