Membrane voltage controls the function of excitable cells and is mainly a consequence of
the ratio between the extra-and intracellular potassium concentration. Potassium …

Kidney organoids derived from human pluripotent stem cells constitute a novel model of
disease, development, and regenerative therapy. Organoids are human, experimentally …

Ca2+-activated BK channels in renal intercalated cells (ICs) mediate luminal flow–induced
K+ secretion (FIKS), but how ICs sense increased flow remains uncertain. We examined …

Mammalian (or mechanistic) target of rapamycin complex 2 (mTORC2) is a kinase complex
that targets predominantly Akt family proteins, SGK1 and protein kinase C (PKC), and has …

Kidney organoids are three-dimensional structures generated from pluripotent stem cells
(PSCs) that are capable of recapitulating the major structures of mammalian kidneys. As this …

The Cl−/HCO 3− exchanger pendrin in the kidney maintains acid-base balance and
intravascular volume. Pendrin is upregulated in models associated with high circulating …

The epithelial Na+ channel (ENaC) promotes the absorption of Na+ in the aldosterone-
sensitive distal nephron, colon, and respiratory epithelia. Deletion of genes encoding …

The diversity of WNK1 transcripts in the kidney has complicated the interpretation of
experimental data. Integration of experimental data with the knowledge of isoform …

Central pacemaker neurons regulate circadian rhythms and undergo diurnal variation in
electrical activity in mammals and flies. 1, 2 Circadian variation in the intracellular chloride …

New concepts related to cell-autonomous K+ signaling and how it interfaces with
aldosterone-dependent regulation are emerging. The underlying signaling pathways and …