Lipid-mediated signalling regulates a plethora of physiological processes, including crucial
aspects of brain function. In addition, dysregulation of lipid pathways has been implicated in …

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as
statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary …

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that
regulate lipid biosynthesis and adipogenesis by controlling the expression of several …

The role of brain cholesterol metabolism in Alzheimer's disease (AD) remains unclear.
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …

High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …

The mevalonate–isoprenoid–cholesterol biosynthesis pathway plays a key role in human
health and disease. The importance of this pathway is underscored by the discovery that two …

Although cholesterol has been involved in the pathophysiology of Alzheimer disease (AD),
its distribution in the cerebral cortex over the course of AD is unknown. We describe an …

A hallmark pathological feature of Alzheimer′ s disease (AD) is the accumulation of
extracellular plaques composed of the amyloid‐beta (Aβ) peptide. Thus, classically …

Increasing evidences suggest that mitochondrial dysfunction plays an important role in the
pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD) …

The global burden of Alzheimer's disease (AD) is growing. Valiant efforts to develop clinical
candidates for treatment have continuously met with failure. Currently available palliative …