Adverse intrauterine events may profoundly impact fetal risk for future adult diseases. The
mechanisms underlying this increased vulnerability are complex and remain poorly …

Children, adolescents and adults living with Fontan circulation face numerous neurological
and developmental challenges. As the population with complex CHD increases thanks to …

Objective Congenital heart disease (CHD) is associated with abnormal brain development
in utero. We applied innovative fetal magnetic resonance imaging (MRI) techniques to …

Neurodevelopmental impairment is a common and important long-term morbidity among
infants with congenital heart disease (CHD). More than half of those with complex CHD will …

Fetal cortical plate segmentation is essential in quantitative analysis of fetal brain maturation
and cortical folding. Manual segmentation of the cortical plate, or manual refinement of …

Human fetal brains show regionally different temporal patterns of sulcal emergence
following a regular timeline, which may be associated with spatiotemporal patterns of gene …

Patients with congenital heart disease (CHD) requiring cardiac surgery in infancy are at high
risk for neurodevelopmental impairments. Neonatal imaging studies have reported …

Normal cortical growth and the resulting folding patterns are crucial for normal brain
function. Although cortical development is largely influenced by genetic factors …

Background Congenital heart disease (CHD) is common and is associated with impaired
early brain development and neurodevelopmental outcomes, yet the exact mechanisms …

Cortical folding is a hallmark of brain topography whose variability across individuals
remains a puzzle. In this paper, we call for an effort to improve our understanding of the pli …