Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria

FI Qassadi, Z Zhu, TM Monaghan - Pathogens, 2023 - mdpi.com
The rising burden of antimicrobial resistance and increasing infectious disease outbreaks,
including the recent COVID-19 pandemic, has led to a growing demand for the development …

Exploring novel microbial metabolites and drugs for inhibiting Clostridioides difficile

AA Abouelkhair, MN Seleem - Msphere, 2024 - journals.asm.org
Clostridioides difficile is an enteric pathogen that can cause a range of illnesses from mild
diarrhea to pseudomembranous colitis and even death. This pathogen often takes …

Antisense inhibition of RNA polymerase α subunit of Clostridioides difficile

R Pal, MN Seleem - Microbiology Spectrum, 2023 - Am Soc Microbiol
Clostridioides difficile, the causative agent of antibiotic-associated diarrhea and
pseudomembranous colitis, has emerged as a major enteric pathogen in recent years …

Loratadine as an Anti-inflammatory Agent Against Clostridium difficile Toxin B

Y Xie, S Irwin, A Chupina Estrada… - The Journal of …, 2024 - academic.oup.com
Background Clostridium difficile infection (CDI) is a debilitating nosocomial infection. C.
difficile produces toxins A and B, which cause inflammation. Existing therapies have issues …

Screening novel antiviral compounds to treat Clostridioides difficile infections

BJ Stolz, AA Abouelkhair, MN Seleem - PloS one, 2024 - journals.plos.org
Clostridioides difficile is a major cause of nosocomial infections, often associated with
individuals who have gut dysbiosis from previous antibiotic therapies. C. difficile infections …

[HTML][HTML] Molecular docking, dynamics and in vitro analysis of multi-target inhibitors for Clostridioides difficile

NC Golchha, HA Odhar, A Nighojkar, S Nighojkar - Bioinformation, 2024 - ncbi.nlm.nih.gov
The opportunistic pathogen, Clostridioides difficile owes its extreme pathogenicity for its
ability to develop antibiotic resistance and recurrent infections. The current antibiotics used …

[HTML][HTML] In silico interaction of catalytic domain of Clostridioides difficile toxins TcdA and TcdB with some selected compounds from the SuperNatural 3.0 database

SS Alkhalil - Kuwait Journal of Science, 2025 - Elsevier
Clostridioides difficile is a pathogenic bacterium responsible for antibiotic-associated
diarrhea globally. The pathogenesis of this bacterium is due to its virulence toxins, which …

[HTML][HTML] Antibiotic cocktail followed by Clostridium butyricum (CBM588) supplementation improves colonic anastomotic healing in mice

CH Chen, JW Chen, CH Lai, CM Tsai, CC Chen… - Journal of Functional …, 2024 - Elsevier
Background Microbiota manipulation through preoperative probiotic supplementation to
reduce surgical site infection has shown promising results in recent years. However, the …