Polygenic score models for Alzheimer's disease: from research to clinical applications

X Zhou, YYT Li, AKY Fu, NY Ip - Frontiers in Neuroscience, 2021 - frontiersin.org
The high prevalence of Alzheimer's disease (AD) among the elderly population and its lack
of effective treatments make this disease a critical threat to human health. Recent …

Pharmacogenomics of cognitive dysfunction and neuropsychiatric disorders in dementia

R Cacabelos - International journal of molecular sciences, 2020 - mdpi.com
Symptomatic interventions for patients with dementia involve anti-dementia drugs to improve
cognition, psychotropic drugs for the treatment of behavioral disorders (BDs), and different …

Earlier chronotype in midlife as a predictor of accelerated brain aging: a population-based longitudinal cohort study

HJ Kim, REY Kim, S Kim, SK Lee, HW Lee, C Shin - Sleep, 2023 - academic.oup.com
Abstract Study Objectives Evidence suggests that sleep–wake cycle disruption could be an
early manifestation of neurodegeneration and might even be a risk factor for developing …

Sleep duration, sleep efficiency, and amyloid β among cognitively healthy later-life adults: a systematic review and meta-analysis

C Moon, A Schneider, YE Cho, M Zhang, H Dang, K Vu - BMC geriatrics, 2024 - Springer
Background Abnormal amyloid β (Aβ) deposits in the brain are a hallmark of Alzheimer's
disease (AD). Insufficient sleep duration and poor sleep quality are risk factors for …

[HTML][HTML] 老年慢性失眠相关认知障碍的危险因素分析

胡裕洁, 杨国帅, 张艳君, 王淑玲 - Journal of International Neurology …, 2020 - html.rhhz.net
目的探讨老年慢性失眠相关认知障碍的危险因素. 方法回顾性筛选老年慢性失眠患者107 例,
根据蒙特利尔认知评估量表(MoCA) 评分将患者分为认知障碍组与非认知障碍组 …

[HTML][HTML] Sleep Duration and Amyloid β Among Cognitively Healthy Later-Life Adults: A Systematic Review and Meta-Analysis

C Moon, A Schneiner, YE Cho, M Zhang, H Dang… - Research …, 2023 - ncbi.nlm.nih.gov
Background Amyloid β (Aβ) is a hallmark of Alzheimer's disease (AD). Insufficient sleep
duration and poor sleep quality have been found to be a risk factor of developing AD …

Investigating polygenic risk scores in Alzheimer's disease

SR Chaudhury - eprints.nottingham.ac.uk
Alzheimer's disease (AD), the most common cause of dementia, is one of the most studied
diseases in the UK due to its impact on quality of life, symptoms of neurodegeneration, and …

Understanding Alzheimer's disease through the genetics of sleep

EE Lee - International psychogeriatrics, 2020 - cambridge.org
Over the past few years, there has been growing excitement around the role of sleep in the
neurodegenerative processes of Alzheimer's disease. Sleep disturbances including shorter …