Targeting mycobacterial membranes and membrane proteins: Progress and limitations

G Kumar, S Kapoor - Bioorganic & medicinal chemistry, 2023 - Elsevier
Among the various bacterial infections, tuberculosis continues to hold center stage. Its
causative agent, Mycobacterium tuberculosis, possesses robust defense mechanisms …

Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis

J Augenstreich, V Briken - Frontiers in cellular and infection …, 2020 - frontiersin.org
Mycobacterium tuberculosis (Mtb) is a very successful pathogen, strictly adapted to humans
and the cause of tuberculosis. Its success is associated with its ability to inhibit host cell …

Small carbohydrate derivatives as potent antibiofilm agents

K Singh, SS Kulkarni - Journal of Medicinal Chemistry, 2022 - ACS Publications
Biofilm formation by most pathogenic bacteria is considered as one of the key mechanisms
associated with virulence and antibiotic resistance. Biofilm-forming bacteria adhere to the …

Different membrane order measurement techniques are not mutually consistent

A Gupta, M Kallianpur, DS Roy, O Engberg… - Biophysical …, 2023 - cell.com
Abstract" Membrane order" is a term commonly used to describe the elastic and mechanical
properties of the lipid bilayer, though its exact meaning is somewhat context-and method …

Fusion Landscape of Mycobacterial Envelope-Derived Lipid Vesicles with Intact Bacteria Dictates High Intracellular Drug Retention

L Mathew, DK Verma, K Liang, M Duan… - ACS Applied Bio …, 2023 - ACS Publications
Membrane vesicles are critical regulators of pathogenic diseases. In tubercular infections,
the use of mycobacteria derived vesicles as delivery vehicles to overcome drug resistance …

Various facets of pathogenic lipids in infectious diseases: exploring virulent lipid-host interactome and their druggability

R Dadhich, S Kapoor - The Journal of membrane biology, 2020 - Springer
Lipids form an integral, structural, and functional part of all life forms. They play a significant
role in various cellular processes such as membrane fusion, fission, endocytosis, protein …

Mycobacterial lipid-derived immunomodulatory drug-liposome conjugate eradicates endosome-localized mycobacteria

M Mishra, AD Gupta, R Dadhich… - … Clinics and Research, 2023 - journals.lww.com
Tuberculosis is a challenging disease due to the intracellular residence of its pathogen,
Mycobacterium tuberculosis, and modulation of the host bactericidal responses. Lipids from …

Chemical tools for illumination of tuberculosis biology, virulence mechanisms, and diagnosis

G Kumar, R Narayan, S Kapoor - Journal of Medicinal Chemistry, 2020 - ACS Publications
Tuberculosis (TB) remains one of the deadliest infectious diseases and begs the scientific
community to up the ante for research and exploration of completely novel therapeutic …

Biophysical Interaction Landscape of Mycobacterial Mycolic Acids and Phenolic Glycolipids with Host Macrophage Membranes

AT Srivatsav, S Kapoor - ACS Applied Bio Materials, 2023 - ACS Publications
Lipidic adjuvant formulations consisting of immunomodulatory mycobacterial cell wall lipids
interact with host cells following administration. The impact of this cross-talk on the host …

Mycobacterium lipids modulate host cell membrane mechanics, lipid diffusivity, and cytoskeleton in a virulence-selective manner

M Mishra, R Dadhich, P Mogha… - ACS infectious …, 2020 - ACS Publications
Microbial lipids play a critical role in the pathogenesis of infectious diseases by modulating
the host cell membrane properties, including lipid/protein diffusion and membrane …