Sensory experience regulates the structural and functional wiring of neuronal circuits, during
development and throughout adulthood. Here, we review current knowledge of how …

Major depressive disorder is viewed as a 'circuitopathy'. The hippocampal-entorhinal
network plays a pivotal role in regulation of depression, and its main sensory output, the …

The mammalian brain is a highly complex network that consists of millions to billions of
densely-interconnected neurons. Precise dissection of neural circuits at the mesoscopic …

Persistent activity underlying short-term memory encodes sensory information or instructs
specific future movement and, consequently, has a crucial role in cognition. Despite …

Recent advances in tissue processing, labeling, and fluorescence microscopy are providing
unprecedented views of the structure of cells and tissues at sub-diffraction resolutions and …

In vivo fluorescent imaging represents a potent means for real-time probe quantification,
facilitating insights into disease pathophysiology and therapeutic responses. Nonetheless …

One obstacle to the development of gene therapies for the central nervous system is the lack
of workflows for quantifying transduction efficiency in affected neural networks and ultimately …

Autism spectrum disorder (ASD) is identified by a set of neurodevelopmental divergences
that typically affect the social communication domain. ASD is also characterized by …

A paradigm shift is occurring in neuroscience and in general in life sciences converting
biomedical research from a descriptive discipline into a quantitative, predictive, actionable …

Understanding brain functions requires detailed knowledge of long-range connectivity
through which different areas communicate. A key step toward illuminating the long-range …