Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of
Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition …

The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both
vertebrates and ticks, and efficient means of transmission between those two very different …

Borrelia burgdorferi, the agent of Lyme disease, differentially expresses numerous genes
and proteins as it cycles between mammalian hosts and tick vectors. Insights on regulatory …

Borrelia burgdorferi, the causative agent of Lyme disease in humans, is maintained in a
complex biphasic life cycle, which alternates between tick and vertebrate hosts. To …

Second messengers are intracellular molecules regulated by external stimuli known as first
messengers that are used for rapid organismal responses to dynamic environmental …

The cpdB gene is pro-virulent in avian pathogenic Escherichia coli and in Salmonella
enterica, where it encodes a periplasmic protein named CpdB. It is structurally related to cell …

ABSTRACT C-di-AMP homeostasis is critical for bacterial stress response, cell wall integrity,
and virulence. Except for osmotic stress response, the molecular mechanisms underlying …

The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress
to persist in the tick phase of its enzootic life cycle. We previously found that the stringent …

ABSTRACT R elapsing f ever (RF), caused by spirochetes of the genus Borrelia, is a
globally distributed, vector-borne disease with high prevalence in developing countries. To …

Borrelia burgdorferi, the etiologic agent of Lyme disease, is a spirochete that modulates
numerous host pathways to cause a chronic, multisystem inflammatory disease in humans …