The need for new antibacterial drugs to treat the increasing global prevalence of drug-
resistant bacterial infections has clearly attracted global attention, with a range of existing …

We are experiencing an antimicrobial resistance (AMR) crisis, brought on by the drying up of
the antibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens …

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NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https …

Aliphatic three-and four-membered rings including cyclopropanes, cyclobutanes, oxetanes,
azetidines and bicyclo [1.1. 1] pentanes have been increasingly exploited in medicinal …

Page 1 2021 ANTIBACTERIAL AGENTS IN CLINICAL AND PRECLINICAL DEVELOPMENT:
an overview and analysis World Health Organization Page 2 A PRE Page 3 2021 …

The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …

The major targets for antibiotics in staphylococci are (i) the cell envelope,(ii) the ribosome
and (iii) nucleic acids. Several novel targets emerged from recent targeted drug discovery …

There is growing global recognition that the continued emergence of multidrug-resistant
bacteria poses a serious threat to human health. Action plans released by the World Health …

Inadequate dosing and incomplete treatment regimens, coupled with the ability of the
tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs, have …

The continued emergence of multi-drug-resistant bacteria is a major public health concern.
The identification and development of new antibiotics, especially those with new modes of …