Membrane androgen receptors unrelated to nuclear steroid receptors
P Thomas - Endocrinology, 2019 - academic.oup.com
Rapid (nongenomic) membrane-initiated androgen actions have been described in nuclear
androgen receptor–null cells. Four distinct proteins have been proposed as membrane …
androgen receptor–null cells. Four distinct proteins have been proposed as membrane …
Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface
The novel Wuhan coronavirus (SARS-CoV-2) has been sequenced, and the virus shares
substantial similarity with SARS-CoV. Here, using a computational model of the spike …
substantial similarity with SARS-CoV. Here, using a computational model of the spike …
The consequence and mechanism of dietary flavonoids on androgen profiles and disorders amelioration
Androgen is a kind of steroid hormone that plays a vital role in reproductive system and
homeostasis of the body. Disrupted androgen balance serves as the causal contributor to a …
homeostasis of the body. Disrupted androgen balance serves as the causal contributor to a …
Ensemble docking in drug discovery: how many protein configurations from molecular dynamics simulations are needed to reproduce known ligand binding?
W Evangelista Falcon, SR Ellingson… - The Journal of …, 2019 - ACS Publications
Ensemble docking in drug discovery or chemical biology uses dynamical simulations of
target proteins to generate binding site conformations for docking campaigns. We show that …
target proteins to generate binding site conformations for docking campaigns. We show that …
Lysine enhances the stimulation of fatty acids on milk fat synthesis via the GPRC6A-PI3K-FABP5 signaling in bovine mammary epithelial cells
X Li, P Li, L Wang, M Zhang, X Gao - Journal of agricultural and …, 2019 - ACS Publications
Amino acids can enhance milk fat synthesis in bovine mammary epithelial cells (BMECs),
but the molecular mechanism is not well-known. In this study, we explored the regulatory …
but the molecular mechanism is not well-known. In this study, we explored the regulatory …
Binding of androgen-and estrogen-like flavonoids to their cognate (non) nuclear receptors: a comparison by computational prediction
Flavonoids are plant bioactives that are recognized as hormone-like polyphenols because
of their similarity to the endogenous sex steroids 17β-estradiol and testosterone, and to their …
of their similarity to the endogenous sex steroids 17β-estradiol and testosterone, and to their …
Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin
N Harada, M Okuyama, Y Teraoka, Y Arahori… - npj Science of …, 2022 - nature.com
The identification of molecular targets of bioactive food components is important to
understand the mechanistic aspect of their physiological functions. Here, we have …
understand the mechanistic aspect of their physiological functions. Here, we have …
(-)-Epicatechin acts as a potent agonist of the membrane androgen receptor, ZIP9 (SLC39A9), to promote apoptosis of breast and prostate cancer cells
P Thomas, J Dong - The Journal of Steroid Biochemistry and Molecular …, 2021 - Elsevier
Epicatechin, a flavonoid present in high concentrations in foods such as green tea and
cocoa, exerts beneficial and protective effects in numerous disease models, including anti …
cocoa, exerts beneficial and protective effects in numerous disease models, including anti …
Pharmacology and physiological function of the orphan GPRC6A receptor
CV Jørgensen… - Basic & Clinical …, 2020 - Wiley Online Library
The G protein‐coupled receptor GPRC6A (GPCR, Class C, group 6, subtype A) is a Gq/11‐
coupled receptor widely expressed in human and rodent tissues. The proposed …
coupled receptor widely expressed in human and rodent tissues. The proposed …
Human GPRC6A mediates testosterone-induced mitogen-activated protein kinases and mTORC1 signaling in prostate cancer cells
G protein-coupled receptor family C group 6 member A (GPRC6A) is activated by
testosterone and modulates prostate cancer progression. Most humans have a GPRC6A …
testosterone and modulates prostate cancer progression. Most humans have a GPRC6A …