c-Jun N-terminal kinases (JNKs), first characterized as stress-activated members of the
mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening …

Background One challenge facing biologists is to tease out useful information from massive
data sets for further analysis. A pathway-based analysis may shed light by projecting …

The dual leucine zipper kinase (DLK) alias mitogen-activated protein 3 kinase 12
(MAP3K12) has gained much attention in recent years. DLK belongs to the mixed lineage …

The development of neuronal polarity is essential for the determination of neuron
connectivity and for correct brain function. The c-Jun N-terminal kinase (JNK)-interacting …

The podocyte proteins Neph1 and nephrin organize a signaling complex at the podocyte
cell membrane that forms the structural framework for a functional glomerular filtration …

JIPs are JNK interacting proteins and bind to JNK cascade kinases. JIP1 and JIP3 were
known to be adaptors linking cargo to Kinesin‐I, a major molecular motor for axonal …

Obesity is a major risk factor for the development of metabolic syndrome and type 2
diabetes. How obesity contributes to metabolic syndrome is unclear. Free fatty acid (FFA) …

Numerous epidemiological studies and some pharmacological clinical trials show the close
connection between Alzheimer disease (AD) and type 2 diabetes (T2D) and thereby, shed …

Abstract C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase
family, are significantly linked with neurological and neurodegenerative pathologies and …

JIP scaffold proteins are implicated in the regulation of protein kinase signal transduction
pathways. To test the physiological role of these scaffold proteins, we examined the …