Identification of potential key genes in prostate cancer with gene expression, pivotal pathways and regulatory networks analysis using integrated bioinformatics …

MM Khan, MT Mohsen, MZ Malik, SA Bagabir… - Genes, 2022 - mdpi.com
Prostate cancer (PCa) is the most prevalent cancer (20%) in males and is accountable for a
fifth (6.8%) cancer-related deaths in males globally. Smoking, obesity, race/ethnicity, diet …

CDK1 and HSP90AA1 appear as the novel regulatory genes in non-small cell lung cancer: a bioinformatics approach

N Bhattacharyya, S Gupta, S Sharma, A Soni… - Journal of Personalized …, 2022 - mdpi.com
Lung cancer is one of the most invasive cancers affecting over a million of the population.
Non-small cell lung cancer (NSCLC) constitutes up to 85% of all lung cancer cases, and …

[HTML][HTML] Identification of key proteins in host–pathogen interactions between Mycobacterium tuberculosis and Homo sapiens: A systematic network theoretical …

RN Verma, MZ Malik, GP Singh, N Subbarao - Healthcare Analytics, 2022 - Elsevier
Tuberculosis (TB) is an infectious disease caused primarily by the bacterial pathogen
Mycobacterium tuberculosis (Mtb) in humans. The emergence of various drug-resistant Mtb …

MotifHub: Detection of trans-acting DNA motif group with probabilistic modeling algorithm

Z Liu, HM Wong, X Chen, J Lin, S Zhang, S Yan… - Computers in Biology …, 2024 - Elsevier
Background Trans-acting factors are of special importance in transcription regulation, which
is a group of proteins that can directly or indirectly recognize or bind to the 8–12 bp core …

Network medicine in ovarian cancer: topological properties to drug discovery

K Chirom, MZ Malik, IR Mangangcha… - Briefings in …, 2022 - academic.oup.com
Network medicine provides network theoretical tools, methods and properties to study
underlying laws governing human interactome to identify disease states and disease …

Application of a maximal-clique based community detection algorithm to gut microbiome data reveals driver microbes during influenza A virus infection

A Bhar, LC Gierse, A Meene, H Wang, C Karte… - Frontiers in …, 2022 - frontiersin.org
Influenza A Virus (IAV) infection followed by bacterial pneumonia often leads to
hospitalization and death in individuals from high risk groups. Following infection, IAV …

Identification of microRNA and gene interactions through bioinformatic integrative analysis for revealing candidate signatures in prostate cancer

MM Khan, M Serajuddin, MZ Malik - Gene Reports, 2022 - Elsevier
Abstract Background Prostate cancer (PCa) is a most common diagnosed cancer among
males globally. Despite the decreased PCa mortality, increased prevalence of it creates …

Discovering driver nodes in chronic kidney disease-related networks using Trader as a newly developed algorithm

Y Masoudi-Sobhanzadeh, A Gholaminejad… - Computers in Biology …, 2022 - Elsevier
Thanks to the advances in the field of computational-based biology, a huge volume of
disease-related data has been generated so far. From the existing data, the disease-related …

[HTML][HTML] Protein network analysis to prioritize key genes in amyotrophic lateral sclerosis

R Kumar, S Haider - IBRO Neuroscience Reports, 2022 - Elsevier
Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal disease, progressive nature
characterizes by loss of both upper and lower motor neuron functions. One of the major …

Tat-hspb1 Suppresses Clear Cell Renal Cell Carcinoma (ccRCC) Growth via Lysosomal Membrane Permeabilization

L Zhang, GZ Jin, D Li - Cancers, 2022 - mdpi.com
Simple Summary In this study, we discovered a novel endogenous peptide derived from
HSPB1 protein through peptidomic analysis of human renal clear cell carcinoma and …