Among the homeostatic processes controlling the endogenous l-carnitine pool in humans,
the kidney has a vital role through extensive and adaptive tubular reabsorption. Kidney …

Carnitine is a vitamin-like substance that regulates lipid metabolism and energy production.
Carnitine homeostasis is mainly regulated by dietary intake and biosynthesis in the organs …

Chronic renal failure (CRF) is a major public health problem worldwide. Earlier studies have
revealed salutary effects of rhubarb extracts in CRF. In this study, we employed lipidomic …

Liver cirrhosis (LC) is a major cause of secondary sarcopenia. Sarcopenia makes the
prognosis worse; thus, novel therapeutic options for sarcopenia in patients with LC are …

BACKGROUND & AIMS: A phase III, randomized non-inferiority study was carried out to
compare a two-drug combination (including nutraceuticals, ie antioxidants) with carnitine+ …

Skeletal muscle in congestive heart failure is responsible for increased fatigability and
decreased exercise capacity. A specific myopathy with increased expression of fast-type …

Hemodialysis (HD) patients often have low serum concentrations of free L‐carnitine and
decreased skeletal muscle stores. As L‐carnitine is an essential cofactor in fatty acid and …

Exercise capacity in patients with end-stage renal disease (ESRD) remains impaired despite
correction ofanemia. Carnitine insufficiency may contribute to impaired exercise and …

In patients with chronic renal failure, not yet undergoing hemodialysis (HD), plasma
acylcarnitines accumulate in part due to a decreased renal clearance of esterified carnitine …

Carnitine is a naturally occurring amino acid derivative that is involved in the transport of
long-chain fatty acids to the mitochondrial matrix. There, these substrates undergo β …