Recent advances in the synthesis of biologically active cinnoline, phthalazine and quinoxaline derivatives

Y Taek Han, JW Jung, NJ Kim - Current Organic Chemistry, 2017 - ingentaconnect.com
In the recent decades, N-heterocycles are widely used as versatile scaffolds for the
development of biologically active compounds and considered as one of the privileged …

A review on multipurpose potential of bioactive heterocycle quinoxaline

G Chawla, O Gupta, T Pradhan - ChemistrySelect, 2023 - Wiley Online Library
In last few decades, nitrogen‐containing heterocycles have maintained their status as an
important core of FDA‐approved drugs and medicinally active compounds. Quinoxaline is …

Efficient protocol for the synthesis of quinoxaline, benzoxazole and benzimidazole derivatives using glycerol as green solvent

HM Bachhav, SB Bhagat, VN Telvekar - Tetrahedron Letters, 2011 - Elsevier
A straightforward, efficient and more sustainable catalyst-free method has been developed
for the synthesis of quinoxaline, benzoxazole, and benzimidazole ring system in glycerol to …

Green Design, Synthesis, and Molecular Docking Study of Novel Quinoxaline Derivatives with Insecticidal Potential against Aphis craccivora

MA Alanazi, WAA Arafa, IO Althobaiti, HA Altaleb… - ACS …, 2022 - ACS Publications
An efficient and environmentally friendly method was established for designing novel 3-
amino-1, 4-dihydroquinoxaline-2-carbonitrile (1) via the reaction of bromomalononitrile and …

Synthesis and biological evaluation of novel 2, 3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents

J Cogo, V Kaplum, DP Sangi, T Ueda-Nakamura… - European Journal of …, 2015 - Elsevier
Quinoxalines belong to the N-containing heterocyclic compounds that stand out as having
promising biological activity due to their privileged scaffold. In this work, we report the …

Design, synthesis, molecular docking of new lipophilic acetamide derivatives affording potential anticancer and antimicrobial agents

HEA Ahmed, SK Ihmaid, AM Omar, AM Shehata… - Bioorganic …, 2018 - Elsevier
Abstract Fifteen new substituted N-2-(2-oxo-3-phenylquinoxalin-1 (2H)-yl) acetamides 5a-f,
6a-f, and 8a-c were synthesized by reacting ethyl 2-(2-oxo-3-phenylquinoxalin-1 (2H)-yl) …

Recent advances in the synthesis of five‐and six‐membered heterocycles as bioactive skeleton: A concise overview

N Jangir, Poonam, S Dhadda, DK Jangid - ChemistrySelect, 2022 - Wiley Online Library
Heterocyclic compounds play a tremendous role in the field of medicinal chemistry due to
their association with diverse pharmacological properties. Most of the pharmaceutical drugs …

New prospective insecticidal agents based on thiazolo [4, 5-b] quinoxaline derivatives against cotton leafworm Spodoptera litura (Fabricius): Design, synthesis …

A Ragab, DM Elsisi, EM Elqady, ELS Eman… - Pesticide Biochemistry …, 2024 - Elsevier
In this study, a new series of thiazolo [4, 5-b] quinoxaline derivatives 3–8 were synthesized
by treating 2, 3-dichloroquinoxaline with thiosemicarbazone and thiourea derivatives under …

Quinoxaline: A chemical moiety with spectrum of interesting biological activities

A Sharma, A Deep, MG Marwaha… - Mini Reviews in …, 2022 - ingentaconnect.com
Quinoxaline (C8H6N2), commonly called 1, 4-diazanaphthalene, 1, 4-benzodiazine, or
benzopyrazine, is a very potent nitrogenous heterocyclic moiety consisting of a benzene ring …

H‐ZSM‐5 zeolite synthesis by sourcing silica from the wheat husk ash: characterization and application as a versatile heterogeneous catalyst in organic …

IR Shaikh, RA Shaikh, AA Shaikh, JA War… - Journal of …, 2015 - Wiley Online Library
ZSM‐5 zeolite was synthesized by sourcing silica from wheat husk ash and was converted
into its protonated form following careful, conventionally accepted ion‐exchange method …