Modulation of the ubiquitin‐proteasome system by phytochemicals: Therapeutic implications in malignancies with an emphasis on brain tumors
Regarding the multimechanistic nature of cancers, current chemo‐or radiotherapies often
fail to eradicate disease pathology, and frequent relapses or resistance to therapies occur …
fail to eradicate disease pathology, and frequent relapses or resistance to therapies occur …
Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases
DL Bolhuis, MJ Emanuele… - Biochemical Society …, 2024 - portlandpress.com
Protein ubiquitination is a post-translational modification that entails the covalent attachment
of the small protein ubiquitin (Ub), which acts as a signal to direct protein stability …
of the small protein ubiquitin (Ub), which acts as a signal to direct protein stability …
UCHL3 promotes cervical cancer development and metastasis by stabilizing NRF2 via deubiquitination
Y Zhang, J Liu, J Liu, M Liu, H Liu, J Zhang - Biochemical and Biophysical …, 2023 - Elsevier
Cervical cancer is one of the most lethal gynaecological malignancies in females. The
deubiquitylase UCHL3 has been studied as an oncogenic factor in multiple cancers …
deubiquitylase UCHL3 has been studied as an oncogenic factor in multiple cancers …
Identification of narciclasine as a novel NRF2 inhibitor
HH Ngo, BY Yu, JE Lee, H Kim, YS Keum - Free Radical Research, 2025 - Taylor & Francis
Cancer genome sequencing studies have identified somatic mutations in the KEAP1/NRF2
pathway. In an effort to identify novel NRF2 small molecule inhibitor (s), we have screened a …
pathway. In an effort to identify novel NRF2 small molecule inhibitor (s), we have screened a …
Synthesis of Electrophilic Cyclopent‐2‐enone Conjugates With Modulatory Effects on Inflammatory Responses Mediated by Nrf2/Keap1, NF‐κB and IL‐6
GLL Neri, YS Chen, HCP Arturo, MTJ Quimque… - …, 2024 - Wiley Online Library
Cyclopent‐2‐enone bearing natural products possess anti‐inflammatory, cytotoxic,
antiproliferative, and antimicrobial activities attributed to the presence of a Michael acceptor …
antiproliferative, and antimicrobial activities attributed to the presence of a Michael acceptor …
Exploring the Comparative Networks of NFE2L Transcription Factors: Protein Interactions and Transcriptomic Insights
H Lahiff - 2023 - search.proquest.com
Following exposure to a variety of stressors, the restoraNon of cellular homeostasis is
mediated through the fine control of transcripNon factors. One such family of transcripNon …
mediated through the fine control of transcripNon factors. One such family of transcripNon …