Organoids are miniaturized and simplified versions of an organ produced in vitro from stem
or progenitor cells. They are used as a model system consisting of multiple cell types …

Organoids are three-dimensional, multicellular constructs that recapitulate the structural and
functional features of specific organs. Because of these characteristics, organoids have …

During preimplantation development, mouse embryos form a fluid-filled lumen. Pressurized
fluid fractures cell–cell contacts and accumulates into pockets, which coarsen into a single …

Organoids are multi-cellular structures that are cultured in vitro from stem cells to resemble
specific organs (eg, brain, liver) in their three-dimensional composition. Dynamic changes in …

During neural tube (NT) development, the notochord induces an organizer, the floorplate,
which secretes Sonic Hedgehog (SHH) to pattern neural progenitors. Conversely, NT …

Viral infections, fertilization, neurotransmission, and many other fundamental biological
processes rely on membrane fusion. Straightforward calculations based on the celebrated …

Mechanical work serves as the foundation for dynamic cellular processes, ranging from cell
division to migration. A fundamental driver of cellular mechanical work is the actin …

The formation of holes in epithelial tissue is essential for development, but it can also be
associated with epithelial barrier dysfunction and cancer progression. Here we show that …

Problem Organoids are 3D cultures that are commonly used for biological and medical
research in vitro due to their functional and structural similarity to source organs. The …

Animal morphogenesis, the development of an organism's body form, is commonly
perceived as a directed and almost deterministic process. However, noise and stochastic …