Combination of light and Ru (II) polypyridyl complexes: Recent advances in the development of new anticancer drugs
L Conti, E Macedi, C Giorgi, B Valtancoli… - Coordination Chemistry …, 2022 - Elsevier
The increasing impact of cancer on worldwide mortality makes the research of novel
chemotherapeutic agents a current and challenging issue. In the recent years, transition …
chemotherapeutic agents a current and challenging issue. In the recent years, transition …
Advances of metallodrug-amyloid β aggregation inhibitors for therapeutic intervention in neurodegenerative diseases: Evaluation of their mechanistic insights and …
Metal ions play a key role in aggregation of amyloid β protein by interfering with their proper
folding, altering protein homeostasis and cell viability, and ultimately leading to …
folding, altering protein homeostasis and cell viability, and ultimately leading to …
Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease
A series of novel scaffold of N-substituted pyrazole derived α-aminophosphonates were
designed, synthesized and evaluated for their anti-cholinesterase activity. Porcine …
designed, synthesized and evaluated for their anti-cholinesterase activity. Porcine …
Inhibition of amyloid β1–42 peptide aggregation by newly designed cyclometallated palladium complexes
Uncontrolled amyloid aggregation is a frequent cause of neurodegenerative disorders such
as prions and Alzheimer's disease (AD). As a result, many drug development approaches …
as prions and Alzheimer's disease (AD). As a result, many drug development approaches …
Importance of hydrogen bonding: structure–activity relationships of ruthenium (III) complexes with pyridine-based ligands for alzheimer's disease therapy
Alzheimer's disease (AD) is the most common form of dementia, where one of the
pathological hallmarks of AD is extracellular protein deposits, the primary component of …
pathological hallmarks of AD is extracellular protein deposits, the primary component of …
Transition Metal Complexes as Therapeutics: A New Frontier in Combatting Neurodegenerative Disorders through Protein Aggregation Modulation
Neurodegenerative disorders (NDDs) are a class of debilitating diseases that progressively
impair the protein structure and result in neurological dysfunction in the nervous system …
impair the protein structure and result in neurological dysfunction in the nervous system …
Design and synthesis of piano-stool ruthenium (II) complexes and their studies on the inhibition of amyloid β (1–42) peptide aggregation
Misfolding and protein aggregation have been linked to numerous human
neurodegenerative disorders such as Alzheimer's, prion, and Parkinson's diseases …
neurodegenerative disorders such as Alzheimer's, prion, and Parkinson's diseases …
Platinum (II) Schiff Base Complexes and their Effects on the Inhibition of Amyloid β1–42 Aggregation
S İrişli, S Günnaz, Ö Özcan, A Arı… - Applied …, 2024 - Wiley Online Library
For synthesizing metal–organic molecules with pro‐drug properties to prevent the
accumulation of amyloid beta (Aβ1–42), which is a feature of neurodegenerative Alzheimer's …
accumulation of amyloid beta (Aβ1–42), which is a feature of neurodegenerative Alzheimer's …
Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases
DL Ma, C Wu, G Li, TL Yung, CH Leung - Journal of Materials …, 2020 - pubs.rsc.org
Neurodegenerative diseases are the result of neurodegeneration, which is the process of
losing neuronal functions gradually due to the irreversible damage and death of neurons …
losing neuronal functions gradually due to the irreversible damage and death of neurons …
Peptide-based materials that exploit metal coordination
GA Bassan, S Marchesan - International Journal of Molecular Sciences, 2022 - mdpi.com
Metal–ion coordination has been widely exploited to control the supramolecular behavior of
a variety of building blocks into functional materials. In particular, peptides offer great …
a variety of building blocks into functional materials. In particular, peptides offer great …