Understanding how and when the left–right (LR) axis is first established is a fundamental
question in developmental biology. A popular model is that the LR axis is established …

The initial breaking of left-right (L–R) symmetry in the embryo is controlled by a motile-cilia-
driven leftward fluid flow in the left-right organiser (LRO), resulting in L–R asymmetric gene …

Unidirectional fluid flow plays an essential role in the breaking of left-right (LR) symmetry in
mouse embryos, but it has remained unclear how the flow is sensed by the embryo. We …

In mammals, left-right (LR) asymmetry is established by posteriorly oriented cilia driving a
leftwards laminar flow in the embryonic node, thereby activating asymmetric gene …

The human PKD2 locus encodes Polycystin-2 (PC2), a TRPP channel that localises to
several distinct cellular compartments, including the cilium. PKD2 mutations cause …

Ciliopathies are a group of clinically and genetically overlapping disorders whose etiologies
lie in defective cilia. These are antenna-like organelles on the apical surface of numerous …

The ciliopathies are an apparently disparate group of human diseases that all result from
defects in the formation and/or function of cilia. They include disorders such as Meckel …

Asymmetric development of the vertebrate embryo has fascinated embryologists for over a
century. Much has been learned since the asymmetric Nodal signaling cascade in the left …

The primary cilium has been found to be associated with a number of cellular signaling
pathways, such as vertebrate hedgehog signaling, and implicated in the pathogenesis of …

Our understanding of motile cilia and their role in disease has increased tremendously over
the last two decades, with critical information and insight coming from the analysis of mouse …