Thoracic aortic aneurysm and dissection (TAAD) affects many patients globally and has high
mortality rates if undetected. Once thought to be solely a degenerative disease that afflicted …

Wound healing is one of the most complex processes in multicellular organisms, involving
numerous intra-and intercellular signalling pathways in various cell types. It involves …

Background: Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary
syndrome that predominantly affects women. Its pathophysiology remains unclear but …

Objective—Aortic aneurysm, focal dilation of the aorta, results from impaired integrity of
aortic extracellular matrix (ECM). Matrix metalloproteinases (MMPs) are traditionally known …

Preservation and development of life depend on the adequate segregation of sister
chromatids during mitosis and meiosis. This process is ensured by the cohesin multi-subunit …

Advances in medical diagnosis reveal that coronary artery aneurysms (CAAs) may develop
in several clinical scenarios and manifest variable symptoms, imaging appearances, and …

Rationale: The pathogenesis of bicuspid aortic valve (BAV)–associated aortopathy is poorly
understood, and no prognostic biomarker is currently available. Objective: We aimed to …

We begin this chapter by describing normal characteristics of several pertinent connective
tissue components, and some of the basic changes they undergo with ageing. These …

The aortopathy associated with bicuspid aortic valve (BAV) is an epidemiologically relevant
source of chronic and acute aortic disease (aneurysm and dissection). However, its …

Patients with the Loeys‐Dietz syndrome (LDS) have mutations in the TGF‐βR1, TGF‐βR2,
and SMAD3 genes. However, little is known about the redox homeostasis in the thoracic …