The possibility of safe discontinuation of therapy with nucleos (t) ide analogues (NAs)
remains one of the most controversial topics in the management of chronic hepatitis B …

The IQGAP family comprises three proteins in humans. The best characterized is IQGAP1,
which participates in protein–protein interactions and integrates diverse signaling pathways …

Whether the brain tumor medulloblastoma originates from stem cells or restricted progenitor
cells is unclear. To investigate this, we activated oncogenic Hedgehog (Hh) signaling in …

Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/β-
catenin signaling. Here, we used microarray analysis to identify two tumor subclasses …

Macrophages serve to maintain organ homeostasis in response to challenges from injury,
inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has …

Recent studies have identified stem cells in brain cancer. However, their relationship to
normal CNS progenitors, including dependence on common lineage-restricted pathways, is …

Following myocardial infarction (MI), myeloid cells derived from the hematopoietic system
drive a sharp increase in systemic leukocyte levels that correlates closely with mortality. The …

Regulation of embryonic diapause, dormancy that interrupts the tight connection between
developmental stage and time, is still poorly understood. Here, we characterize the …

Although cell-lineage and differentiation models dominate tumour classification and
treatment, the recognition that cancer is also a genomic disease has prompted a …

Background The expression of carcino-embryonic antigen by colorectal cancer is an
example of oncogenic activation of embryonic gene expression. Hypothesizing that …