Voltage-gated sodium channels are protein complexes comprised of one pore forming α
subunit and two, non-pore forming, β subunits. The voltage-gated sodium channel β …

Background The epilepsies are a clinically heterogeneous group of neurological disorders.
Despite strong evidence for heritability, genome-wide association studies have had little …

Abstract Purpose of Review The goal of this focused review is to describe recent studies
supporting a critical role of microRNAs in the regulation of ion channels and discuss the …

Lung cancer is one of the most common malignancies worldwide. The present study aimed
to investigate specific genotypes of different subtypes or stages of lung cancer through gene …

Abstract Purpose Drug Resistant-Epilepsy is still a major challenge in pharmacotherapy of
epilepsy. Pharmacogenetic pathways are one of the most important elements that can help …

To investigate the mechanisms by which β-subunits influence Nav channel function, we
solved the crystal structure of the β2 extracellular domain at 1.35 Å. We combined these data …

Purpose Despite the advances in the pharmacological treatment of epilepsy,
pharmacoresistance still remains challenging. Understanding of the pharmacogenetic …

Deletions encompassing the BP1-2 region at 15q11. 2 increase schizophrenia and epilepsy
risk, but only some carriers have either disorder. To investigate the role of CYFIP1, a gene …

Background Mutations in the neuronal sodium voltage-gated channel, alpha subunit 1
(SCN1A) gene have been associated with epilepsy. We investigated the SCN1A-A3184G …

As a pathological condition, epilepsy is caused by abnormal neuronal discharge in brain
which will temporarily disrupt the cerebral functions. Epilepsy is a chronic disease which …