Deconstruction and reassembly of renewable polymers and biocolloids into next generation structured materials

BL Tardy, BD Mattos, CG Otoni, M Beaumont… - Chemical …, 2021 - ACS Publications
This review considers the most recent developments in supramolecular and supraparticle
structures obtained from natural, renewable biopolymers as well as their disassembly and …

Applications of synchrotron powder X-ray diffractometry in drug substance and drug product characterization

B Munjal, R Suryanarayanan - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
While X-ray powder diffractometry (XRD) is a powerful technique for characterizing
crystalline phases, the sensitivity of the laboratory instruments can be a serious limitation …

Recent approaches of matrix release tablet in NDDS system

S Shekhar, A Kumar, V Rana, R Kumar, C Mittal… - Journal for Research in …, 2023 - jrasb.com
The purpose of this analysis is to categorize matrix tablets according to the kind of polymer
they are made of as well as the rate at which they release their contents. When it came to …

Mechanistic Investigation of tert-Butanol's Impact on Biopharmaceutical Formulations: When Experiments Meet Molecular Dynamics

M Rospiccio, P Casucci, A Arsiccio… - Molecular …, 2023 - ACS Publications
The use of tert-butyl alcohol for the lyophilization of pharmaceuticals has seen an uptick over
the past years. Its advantages include increased solubility of hydrophobic drugs, enhanced …

t-Butanol Enables Dual Functionality of Mannitol: A Cryoprotectant in Frozen Systems and Bulking Agent in Freeze-Dried Formulations

J Sonje, S Thakral, R Suryanarayanan - Molecular pharmaceutics, 2020 - ACS Publications
The effect of tertiary butyl alcohol (TBA) as a cosolvent on the phase behavior of mannitol in
frozen and freeze-dried systems was characterized using differential scanning calorimetry …

[HTML][HTML] Impact of a tert-butyl alcohol-cyclohexane system used in unidirectional freeze-casting of SiOC on compressive strength and mass transport

PH da Rosa Braun, K Rezwan, M Wilhelm - Materials & Design, 2021 - Elsevier
Macroporous SiOC monoliths were prepared by solution-based freeze-casting of a
polymethyl siloxane using cyclohexane (CH) and tert-butyl alcohol (TBA) as a novel …

Enabling efficient design of biological formulations through advanced characterization

J Sonje, S Thakral, S Krueger… - Pharmaceutical …, 2023 - Springer
The present review summarizes the use of differential scanning calorimetry (DSC) and
scattering techniques in the context of protein formulation design and characterization. The …

Mechanochemical esterification of cellulose nanofibers lyophilized from eutectic water–tert-butanol mixtures

M Mavlan, T Chang, R Feng, JR Wilkinson… - Cellulose, 2023 - Springer
Freeze-dried CNFs can be modified by mechanochemical (MC) processes with minimal use
of auxiliary solvents, however aggregation of nanofibers during lyophilization compromises …

[HTML][HTML] Non-salt based co-amorphous formulation produced by freeze-drying

MS Alsalhi, PG Royall, H Al-Obaidi, A Alsalhi… - International Journal of …, 2023 - Elsevier
Amino acids-based co-amorphous system (CAM) has shown to be a promising approach to
overcome the dissolution challenge of biopharmaceutics classification system class II drugs …

Unraveling hydrate stoichiometry in water/alkyl alcohol systems by thermodynamic modeling

A Nasr, A Alhadid - Journal of Molecular Liquids, 2024 - Elsevier
The solid–liquid equilibrium (SLE) phase diagram of water/alkyl alcohol systems indicated
the formation of several hydrates. However, due to kinetic limitations and significantly low …