Advanced glycation end products (AGEs) are stable posttranslational modifications of
proteins formed by the spontaneous reaction with glucose and related metabolites …

Inflammatory diseases have become increasingly prevalent with industrialization. To
address this, numerous anti-inflammatory agents and molecular targets have been …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing
prevalence in western societies. Statins are widely applied in atherosclerosis therapy …

By gating the traffic of molecules and cells across the vessel wall, endothelial cells play a
central role in regulating cardiovascular functions and systemic homeostasis and in …

Inflammation has been long regarded as a key contributor to atherosclerosis. Inflammatory
cells and soluble mediators play critical roles throughout arterial plaque development and …

Cadmium (Cd) is an important industrial and environmental pollutant that can produce a
wide variety of adverse effects in humans and animals. A growing volume of evidence …

Abstract Interferon-gamma (IFN-γ) is a pleiotropic cytokine that plays a critical role in
mediating an array of immune responses including promotes antiviral activity, facilitates …

The cytoskeleton is vital to the function of virtually all cell types in the organism as it is
required for cell division, cell motility, endo-or exocytosis and the maintenance of cell shape …

The endothelial barrier of the vasculature is of utmost importance for separating the blood
stream from underlying tissues. This barrier is formed by tight and adherens junctions (TJ …