Engineering precision nanoparticles for drug delivery

MJ Mitchell, MM Billingsley, RM Haley… - Nature reviews drug …, 2021 - nature.com
In recent years, the development of nanoparticles has expanded into a broad range of
clinical applications. Nanoparticles have been developed to overcome the limitations of free …

Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

S Waheed, Z Li, F Zhang, A Chiarini, U Armato… - Journal of …, 2022 - Springer
The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel
solutions potentially capable of revolutionizing health care by improving efficacy …

Nanocrystals: A perspective on translational research and clinical studies

M Jarvis, V Krishnan, S Mitragotri - … & translational medicine, 2019 - Wiley Online Library
Poorly soluble small molecules typically pose translational hurdles owing to their low
solubility, low bioavailability, and formulation challenges. Nanocrystallization is a versatile …

Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system

C Tian, S Zheng, X Liu, K Kamei - Journal of Nanobiotechnology, 2022 - Springer
Despite explosive growth in the development of nano-drug delivery systems (NDDS)
targeting tumors in the last few decades, clinical translation rates are low owing to the lack of …

Human adipose-derived stem cell spheroids incorporating platelet-derived growth factor (PDGF) and bio-minerals for vascularized bone tissue engineering

J Lee, S Lee, T Ahmad, SKM Perikamana, J Lee… - Biomaterials, 2020 - Elsevier
Stem cells with mineralized materials have been used for bone regeneration; however,
engineering the complex vascularized structure of the natural bone remains a challenge …

Biomolecular interactions of ultrasmall metallic nanoparticles and nanoclusters

AA Sousa, P Schuck, SA Hassan - Nanoscale Advances, 2021 - pubs.rsc.org
The use of nanoparticles (NPs) in biomedicine has made a gradual transition from proof-of-
concept to clinical applications, with several NP types meeting regulatory approval or …

Progress and Challenges in the Diagnosis and Treatment of Brain Cancer Using Nanotechnology

Y Ale, N Nainwal - Molecular Pharmaceutics, 2023 - ACS Publications
Primary brain cancer or brain cancer is the overgrowth of abnormal or malignant cells in the
brain or its nearby tissues that form unwanted masses called brain tumors. People with …

Addressing the in vivo delivery of nucleic-acid nanostructure therapeutics

S Alexander, MG Moghadam, M Rothenbroker… - Advanced Drug Delivery …, 2023 - Elsevier
DNA and RNA nanostructures are being investigated as therapeutics, vaccines, and drug
delivery systems. These nanostructures can be functionalized with guests ranging from …

Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles

M Abdelkarim, L Perez-Davalos… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Organ-on-a-chip (OOC) models are based on microfluidics and can recapitulate
the healthy and diseased microstructure of organs1 and tissues and the dynamic …

Nanodiamonds inhibit the proliferation and migration of endothelial cells in a tumor/endothelial cells co-culture microfluidic system

Q Guo, L Li, G Gao, Q Zhao, X Huang, H Wang, B Liu… - Carbon, 2024 - Elsevier
The effect of nanoparticles on co-cultured tumor and endothelial cells has not been
consistently elucidated. To address this question, a microfluidic chip for the co-culture of …