Impact of early life stress on reward circuit function and regulation

JL Hanson, AV Williams, DA Bangasser… - Frontiers in …, 2021 - frontiersin.org
Early life stress–including experience of child maltreatment, neglect, separation from or loss
of a parent, and other forms of adversity–increases lifetime risk of mood, anxiety, and …

Neurodevelopmental origins of substance use disorders: Evidence from animal models of early‐life adversity and addiction

SC Levis, TZ Baram, SV Mahler - European Journal of …, 2022 - Wiley Online Library
Addiction is a chronic relapsing disorder with devastating personal, societal, and economic
consequences. In humans, early‐life adversity (ELA) such as trauma, neglect, and resource …

Chronic ethanol induces a pro-inflammatory switch in interleukin-1β regulation of GABAergic signaling in the medial prefrontal cortex of male mice

FP Varodayan, AR Pahng, TD Davis, P Gandhi… - Brain, behavior, and …, 2023 - Elsevier
Neuroimmune pathways regulate brain function to influence complex behavior and play a
role in several neuropsychiatric diseases, including alcohol use disorder (AUD). In …

Enduring disruption of reward and stress circuit activities by early-life adversity in male rats

SC Levis, MT Birnie, JL Bolton, CR Perrone… - Translational …, 2022 - nature.com
In humans, early-life adversity (ELA) such as trauma, poverty, and chaotic environment is
linked to increased risk of later-life emotional disorders including depression and substance …

Pueraria Extract Ameliorates Alcoholic Liver Disease via the Liver–Gut–Brain Axis: Focus on Restoring the Intestinal Barrier and Inhibiting Alcohol Metabolism

Q Wu, P Li, X Li, L Ma, K Chen… - Journal of Agricultural and …, 2024 - ACS Publications
Alcoholic liver disease (ALD) is one of the causes of hepatocellular carcinoma,
accompanied by intestinal leakage and microbial changes. Pueraria has protective effects …

Lateral habenula beyond avoidance: Roles in stress, memory, and decision-making with implications for psychiatric disorders

PM Baker, V Mathis, L Lecourtier… - Frontiers in systems …, 2022 - frontiersin.org
In this Perspective review, we highlight some of the less explored aspects of lateral
habenula (LHb) function in contextual memory, sleep, and behavioral flexibility. We provide …

[HTML][HTML] Resilience to the effects of social stress on vulnerability to developing drug addiction

C Calpe-López, MA Martínez-Caballero… - World Journal of …, 2022 - ncbi.nlm.nih.gov
We review the still scarce but growing literature on resilience to the effects of social stress on
the rewarding properties of drugs of abuse. We define the concept of resilience and how it is …

Assessing negative affect in mice during abstinence from alcohol drinking: Limitations and future challenges

S Bloch, KM Holleran, TL Kash, EM Vazey, JA Rinker… - Alcohol, 2022 - Elsevier
Alcohol use disorder (AUD) is frequently comorbid with mood disorders, and these co-
occurring neuropsychiatric disorders contribute to the development and maintenance of …

[HTML][HTML] The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females

ME Castle, ME Flanigan - Neurobiology of Stress, 2024 - Elsevier
Abstract Alcohol Use Disorder (AUD) is a leading cause of death and disability worldwide,
but current treatments are insufficient in fully addressing the symptoms that often lead to …

Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development

SC Simmons, GG Grecco, BK Atwood, FS Nugent - Neuropharmacology, 2023 - Elsevier
In this review, we focus on prenatal opioid exposure (POE) given the significant concern for
the mental health outcomes of children with parents affected by opioid use disorder (OUD) in …