Lipids are essential metabolites, which function as energy sources, structural components and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …
V Ratziu, L De Guevara, R Safadi, F Poordad… - Nature medicine, 2021 - nature.com
Nonalcoholic steatohepatitis (NASH), a chronic liver disease without an approved therapy, is associated with lipotoxicity and insulin resistance and is a major cause of cirrhosis and …
U Sen, C Coleman, T Sen - Trends in cancer, 2023 - cell.com
Cancer progression is a highly balanced process and is maintained by a sequence of finely tuned metabolic pathways. Stearoyl coenzyme A desaturase-1 (SCD1), the fatty enzyme that …
L Tesfay, BT Paul, A Konstorum, Z Deng, AO Cox… - Cancer research, 2019 - AACR
Activation of ferroptosis, a recently described mechanism of regulated cell death, dramatically inhibits growth of ovarian cancer cells. Given the importance of lipid metabolism …
The objective of this comprehensive review is to summarize and discuss the available evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …
G Ravaut, A Légiot, KF Bergeron… - International journal of …, 2020 - mdpi.com
Obesity is an important aspect of the metabolic syndrome and is often associated with chronic inflammation. In this context, inflammation of organs participating in energy …
CD Shelton, E Sing, J Mo, NG Shealy, W Yoo… - Cell Host & Microbe, 2023 - cell.com
The mechanisms by which the early-life microbiota protects against environmental factors that promote childhood obesity remain largely unknown. Using a mouse model in which …
Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome. Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened …