Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T
cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility …

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Gut microbiota dysbiosis and metabolic dysfunction in infancy precedes childhood atopy
and asthma development. Here we examined gut microbiota maturation over the first year of …

Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant
glycosylation occurs in essentially all types of cancers and results in increased sialylation …

Peroxisomes are essential metabolic organelles, well known for their roles in the
metabolism of complex lipids and reactive ionic species. In the past 10 years, peroxisomes …

Expressed on epidermal Langerhans cells, CD1a presents a range of self-lipid antigens
found within the skin; however, the extent to which CD1a presents microbial ligands from …

The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an
extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These …

The human body frequently encounters harmful bacterial pathogens and employs immune
defense mechanisms designed to counteract such pathogenic assault. In the adaptive …

CD1-and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic
antigens, such as lipids and small metabolites, and account for a major fraction of circulating …

Phospholipids comprise a large body of lipids that define cells and organelles by forming
membrane structures. Importantly, their complex metabolism represents a highly controlled …