Recent advances in efficiency and ease of implementation have rekindled interest in ion
mobility spectrometry, a technique that separates gas phase ions by their size and shape …

Malignant tumors can evade destruction by the immune system by attracting immune-
suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription factor plays a …

Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive
immunity, and increased inflammation and myeloid pathologies,. Age-related changes in …

With aging, hematopoietic stem cells (HSCs) have an impaired ability to regenerate,
differentiate, and produce an entire repertoire of mature blood and immune cells. Owing to …

The bone marrow in the skull is important for shaping immune responses in the brain and
meninges, but its molecular makeup among bones and relevance in human diseases …

In contrast to the short-term (ST) CD34+ stem cells, studies have suggested that long-term
(LT) hematopoietic stem cells (HSCs) found in the CD34− stem cell pool have trouble …

Loss of protein function is a driving force of ageing. We have identified peptidyl-prolyl
isomerase A (PPIA or cyclophilin A) as a dominant chaperone in haematopoietic stem and …

Tracking stem cell fate transition is crucial for understanding their development and
optimizing biomanufacturing. Destructive single-cell methods provide a pseudotemporal …

Aged hematopoietic stem cells (HSCs) exhibit compromised reconstitution capacity. The
molecular mechanisms behind this phenomenon are not fully understood. Here, we …

CS/ICs have raised great expectations in cancer research and therapy, as eradication of this
key cancer cell type is expected to lead to a complete cure. Unfortunately, the biology of …