Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis.
Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and …

The brain is, by weight, only 2% the volume of the body and yet it consumes about 20% of
the total glucose, suggesting that the energy requirements of the brain are high and that …

Neurons need a continuous supply of glucose, the major source of energy for mammalian
brain metabolism. The central nervous system is protected by three main physiological cell …

Background: Endothelial cells depend on glycolysis for much of their energy production.
Impaired endothelial glycolysis has been associated with various vascular pathobiologies …

The endothelial cell response to glucose plays an important role in both health and disease.
Endothelial glucose-induced dysfunction was first studied in diabetic animal models and in …

Apigenin is a flavonoid with antioxidant, anti-inflammatory, and anti-apoptotic activity. In this
study, the potential effects of apigenin on cardiometabolic diseases were investigated in vivo …

Rationale: Mitochondrial dysfunction facilitates heart failure development forming a
therapeutic target, but the mechanism involved remains unclear. We studied whether the …

Chemokines mediate monocyte adhesion to dysfunctional endothelial cells (ECs) and
promote arterial inflammation during atherosclerosis. Hypoxia-inducible factor (HIF)-1α is …

Glucose is the universal fuel of most mammalian cells, and it is largely replenished through
dietary intake. Glucose availability to tissues is paramount for the maintenance of …