Cell signaling via inositol phosphates, in particular via the second messenger myo‐inositol
1, 4, 5‐trisphosphate, and phosphoinositides comprises a huge field of biology. Of the nine …

The past decade witnessed a renaissance in the chemistry and biochemistry of inositols,
mainly due to the realization of the role played by phosphorylated myo-inositol (1, Chart 1) …

Covering: 2006 up to June 2010, but also including representative examples of prior work
Polyphosphorylated myo-inositol compounds, including the inositol polyphosphates (InsPs) …

Abstract Activated PI3Kδ Syndrome (APDS) is a rare inherited inborn error of immunity
caused by mutations that constitutively activate the p110 delta isoform of phosphoinositide 3 …

Lipids play critical roles in a litany of physiological and pathophysiological events, often
through the regulation of protein function. These activities are generally difficult to …

Cyclitols, described as polyhydroxy-substituted cycloalkanes with at least three hydroxy
groups, each attached to a different ring carbon atom, have for the past decades attracted …

Phosphatidylinositol polyphosphate lipids, such as phosphatidylinositol 3, 4, 5-trisphosphate
[PI (3, 4, 5) P3], regulate critical biological processes, many of which are aberrant in disease …

The synthesis of the complete family of phosphatidylinositol phosphate analogues (PIPs)
from five key core intermediates A–E is described. These core compounds were obtained …

Highly direct asymmetric syntheses of phosphatidylinositol-3-phosphate (PI3P) in each
enantiomerically pure form have been achieved. The key step involves catalytic asymmetric …

The clinical use of anticancer lipids is severely limited by their ability to cause lysis of red
blood cells prohibiting intravenous injection. Novel delivery systems are therefore required …