The poor aqueous solubility of many approved drugs and most new chemical entities poses
a challenge to drug delivery scientists working in academic and industrial labs. Despite the …

Purpose Age-related eye diseases are becoming more prevalent. A notable increase has
been seen in the most common causes including glaucoma, age-related macular …

Gene therapy is now an effective approach to treat many forms of retinal degeneration.
Delivery agents that are cell-specific, allow for multiple dosing regimens, and have low …

Photodynamic therapy (PDT) is commonly used in choroidal neovascularization (CNV)
treatment due to the superior light transmittance of the eye. However, PDT often leads to …

Abstract According to International Diabetes Federation Diabetes Atlas statistics, diabetic
retinopathy (DR) is the leading cause of vision loss in blinding diseases. The underlying …

Posterior segment diseases, such as age-related macular degeneration (AMD) and diabetic
retinopathy (DR) are vital factor that seriously threatens human vision health and quality of …

The delivery of cures for retinal diseases remains problematic. There are four main
challenges: passing through multiple barriers of the eye, the delivery to particular retinal cell …

Abstract Inherited Retinal Diseases (IRDs) are considered one of the leading causes of
blindness worldwide. However, the majority of them still lack a safe and effective treatment …

Oxidative stress is a hallmark of the pathophysiogenesis of retinal ischemia. The direct
delivery of antioxidant enzymes such as superoxide dismutase (SOD) into retinal cells …

Age-related macular degeneration (AMD) is a chronic, progressive retinal disease
characterized by an inflammatory response mediated by activated macrophages and …