Sex hormone signaling and regulation of immune function

JP Hoffmann, JA Liu, K Seddu, SL Klein - Immunity, 2023 - cell.com
Immune responses to antigens, including innocuous, self, tumor, microbial, and vaccine
antigens, differ between males and females. The quest to uncover the mechanisms for …

Regulatory T cells in embryo implantation and the immune response to pregnancy

SA Robertson, AS Care… - The Journal of clinical …, 2018 - Am Soc Clin Investig
At implantation, the embryo expresses paternally derived alloantigens and evokes
inflammation that can threaten reproductive success. To ensure a robust placenta and …

Cytokines, hormones and cellular regulatory mechanisms favoring successful reproduction

MP Piccinni, R Raghupathy, S Saito… - Frontiers in …, 2021 - frontiersin.org
Its semi-allogeneic nature renders the conceptus vulnerable to attack by the maternal
immune system. Several protective mechanisms operate during gestation to correct the …

Progesterone-related immune modulation of pregnancy and labor

NM Shah, PF Lai, N Imami, MR Johnson - Frontiers in endocrinology, 2019 - frontiersin.org
Pregnancy involves a complex interplay between maternal neuroendocrine and
immunological systems in order to establish and sustain a growing fetus. It is thought that the …

Pregnancy, viral infection, and COVID-19

RW Alberca, NZ Pereira, LMDS Oliveira… - Frontiers in …, 2020 - frontiersin.org
Pregnancy comprises a unique immunological condition, to allow fetal development and to
protect the host from pathogenic infections. Viral infections during pregnancy can disrupt …

The T helper type 17/regulatory T cell paradigm in pregnancy

AS Figueiredo, A Schumacher - Immunology, 2016 - Wiley Online Library
Summary T helper type 17 (Th17) and regulatory T (Treg) cells are active players in the
establishment of tolerance and defence. These attributes of the immune system enmesh to …

Progesterone-based therapy protects against influenza by promoting lung repair and recovery in females

OJ Hall, N Limjunyawong, MS Vermillion… - PLoS …, 2016 - journals.plos.org
Over 100 million women use progesterone therapies worldwide. Despite having
immunomodulatory and repair properties, their effects on the outcome of viral diseases …

Dydrogesterone: pharmacological profile and mechanism of action as luteal phase support in assisted reproduction

G Griesinger, H Tournaye, N Macklon… - Reproductive …, 2019 - Elsevier
The pharmacological and physiological profiles of progestogens used for luteal phase
support during assisted reproductive technology are likely to be important in guiding clinical …

The effects of progesterone on immune cellular function at the maternal-fetal interface and in maternal circulation

K Motomura, D Miller, J Galaz, TN Liu… - The Journal of steroid …, 2023 - Elsevier
Progesterone is a sex steroid hormone that plays a critical role in the establishment and
maintenance of pregnancy. This hormone drives numerous maternal physiological …

Sex hormones and lung inflammation

J Reyes-Garcia, LM Montano… - Lung Inflammation in …, 2021 - Springer
Inflammation is a characteristic marker in numerous lung disorders. Several immune cells,
such as macrophages, dendritic cells, eosinophils, as well as T and B lymphocytes …