Macrophages belong to the mononuclear phagocyte system that includes the blood
monocytes and the various kinds of mobile and sessile macrophages. They are recruited …

Objective: To review the biochemistry and biological activities of leukotrienes, focusing on
their role in the mediation of inflammatory diseases. Data Sources: MEDLINE (1966-1994) …

Aspirin causes bronchoconstriction in aspirin-intolerant asthma (AIA) patients by triggering
cysteinyl-leukotriene (cys-LT) production, probably by removing PGE2-dependent inhibition …

BACKGROUND: Leukotrienes (LTs) are potent proinflammatory lipid mediators with key
roles in the pathogenesis of asthma and inflammation. Recently, nanovesicles (exosomes) …

Owing to their anti-inflammatory properties, leukotriene modifiers have been the primary
therapeutics in asthma management for several years. Although blocking the inflammatory …

Human neutrophils from peripheral blood may physically interact with platelets in several
settings including hemostasis, inflammation, and a variety of vascular disorders. A role for …

Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-
lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is …

Since a review on this topic in this Journal appeared (Wolfe, 1982), the CNS has proved to
be a major focus in eicosanoid research. Although our knowledge is limited at the moment …

Activated neutrophils have the ability to upregulate the expression of many genes, in
particular those encoding cytokines and chemokines, and to subsequently release the …

Epoxide hydrolases catalyse the hydrolysis of electrophilic—and therefore potentially
genotoxic—epoxides to the corresponding less reactive vicinal diols, which explains the …