Microfluidic organ-on-a-chip models of human liver tissue
The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
Liver 'organ on a chip'
The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting
The functional maturation and preservation of hepatic cells derived from human induced
pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug screening and …
pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug screening and …
[HTML][HTML] Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells
Life-long reconstitution of a tissue's resident stem cell compartment with engrafted cells has
the potential to durably replenish organ function. Here, we demonstrate the engraftment of …
the potential to durably replenish organ function. Here, we demonstrate the engraftment of …
Engineered liver-on-a-chip platform to mimic liver functions and its biomedical applications: A review
J Deng, W Wei, Z Chen, B Lin, W Zhao, Y Luo, X Zhang - Micromachines, 2019 - mdpi.com
Hepatology and drug development for liver diseases require in vitro liver models. Typical
models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte …
models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte …
Induced pluripotent stem cells for cardiovascular disease modeling and precision medicine: a scientific statement from the American Heart Association
K Musunuru, F Sheikh, RM Gupta… - Circulation: Genomic …, 2018 - Am Heart Assoc
Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …
physiology and disease at the cellular level. They also have the potential to be leveraged in …
In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system
Liver organoids derived from human pluripotent stem cells (PSCs) represent a new type of in
vitro liver model for understanding organ development, disease mechanism and drug …
vitro liver model for understanding organ development, disease mechanism and drug …
Cell and tissue engineering for liver disease
Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …
function, advances in liver physiology, stem cell biology and reprogramming, and the …
Novel 3D culture systems for studies of human liver function and assessments of the hepatotoxicity of drugs and drug candidates
VM Lauschke, DFG Hendriks, CC Bell… - Chemical research in …, 2016 - ACS Publications
The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …
response to a given drug is often determined by its hepatic metabolism. Patient-specific …
Human organoids for predictive toxicology research and drug development
T Matsui, T Shinozawa - Frontiers in Genetics, 2021 - frontiersin.org
Organoids are three-dimensional structures fabricated in vitro from pluripotent stem cells or
adult tissue stem cells via a process of self-organization that results in the formation of organ …
adult tissue stem cells via a process of self-organization that results in the formation of organ …