Novel CRISPR–Cas systems: an updated review of the current achievements, applications, and future research perspectives
According to Darwin's theory, endless evolution leads to a revolution. One such example is
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
Gene editing and CRISPR in the clinic: current and future perspectives
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
Engineered materials for in vivo delivery of genome-editing machinery
Genome-editing technologies, such as CRISPR–Cas9, are promising for treating otherwise
incurable genetic diseases. Great progress has been made for ex vivo genome editing; …
incurable genetic diseases. Great progress has been made for ex vivo genome editing; …
[HTML][HTML] Advances in CRISPR/Cas-based gene therapy in human genetic diseases
CRISPR/Cas genome editing is a simple, cost effective, and highly specific technique for
introducing genetic variations. In mammalian cells, CRISPR/Cas can facilitate non …
introducing genetic variations. In mammalian cells, CRISPR/Cas can facilitate non …
Is Alzheimer's disease a liver disease of the brain?
MF Bassendine, SD Taylor-Robinson… - Journal of …, 2020 - content.iospress.com
Clinical specialization is not only a force for progress, but it has also led to the fragmentation
of medical knowledge. The focus of research in the field of Alzheimer's disease (AD) is …
of medical knowledge. The focus of research in the field of Alzheimer's disease (AD) is …
Delivery of mRNA therapeutics for the treatment of hepatic diseases
Z Trepotec, E Lichtenegger, C Plank, MK Aneja… - Molecular Therapy, 2019 - cell.com
Promising improvements in the field of transcript therapeutics have clearly enhanced the
potential of mRNA as a new pillar for protein replacement therapies. Synthetic mRNAs are …
potential of mRNA as a new pillar for protein replacement therapies. Synthetic mRNAs are …
[HTML][HTML] Advance trends in targeting homology-directed repair for accurate gene editing: An inclusive review of small molecules and modified CRISPR-Cas9 systems
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Introduction: Clustered regularly interspaced short palindromic repeat and its associated …
Introduction: Clustered regularly interspaced short palindromic repeat and its associated …
A review on molecular scissoring with CRISPR/Cas9 genome editing technology
Genome editing is a technology to make specific changes in the DNA of a cell or an
organism. It has significantly altered the landscape of life sciences, facilitating the …
organism. It has significantly altered the landscape of life sciences, facilitating the …
Applications of CRISPR-Cas9 as an advanced genome editing system in life sciences
K Tavakoli, A Pour-Aboughadareh, F Kianersi… - BioTech, 2021 - mdpi.com
Targeted nucleases are powerful genomic tools to precisely change the target genome of
living cells, controlling functional genes with high exactness. The clustered regularly …
living cells, controlling functional genes with high exactness. The clustered regularly …
CRISPR/Cas-Dependent and Nuclease-Free In Vivo Therapeutic Gene Editing
Precise gene manipulation by gene editing approaches facilitates the potential to cure
several debilitating genetic disorders. Gene modification stimulated by engineered …
several debilitating genetic disorders. Gene modification stimulated by engineered …