New perspectives on the importance of cell-free DNA biology

AJ Bronkhorst, V Ungerer, A Oberhofer, S Gabriel… - Diagnostics, 2022 - mdpi.com
Body fluids are constantly replenished with a population of genetically diverse cell-free DNA
(cfDNA) fragments, representing a vast reservoir of information reflecting real-time changes …

Telomeres, oxidative stress, and timing for spontaneous term and preterm labor

M Phillippe - American Journal of Obstetrics and Gynecology, 2022 - Elsevier
Telomeres are nucleoprotein complexes located at the distal ends of chromosomes. In
adults, progressive telomere shortening occurs throughout the lifetime and is thought to …

Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus

S Huang, J Chen, Z Cui, K Ma, D Wu, J Luo, F Li… - Science …, 2023 - science.org
Inflammation-associated insulin resistance is a key trigger of gestational diabetes mellitus
(GDM), but the underlying mechanisms and effective interventions remain unclear. Here, we …

[HTML][HTML] Dimethylamino group modified polydopamine nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy

Y Chen, Y Wang, X Jiang, J Cai, Y Chen, H Huang… - Bioactive Materials, 2022 - Elsevier
Excessive cell-free DNA (cfDNA) released by damaged or apoptotic cells can cause
inflammation, impacting the progression of rheumatoid arthritis (RA). cfDNA scavengers …

Is human labor at term an inflammatory condition?

C Kyathanahalli, M Snedden, E Hirsch - Biology of reproduction, 2023 - academic.oup.com
Parturition at term in normal pregnancy follows a predictable sequence of events. There is
some evidence that a state of inflammation prevails in the reproductive tissues during labor …

Cell-free fetal DNA and spontaneous preterm birth

SR van Boeckel, DJ Davidson, JE Norman… - …, 2018 - rep.bioscientifica.com
Inflammation is known to play a key role in preterm and term parturition. Cell-free fetal DNA
(cff-DNA) is present in the maternal circulation and increases with gestational age and some …

Cell‐free fetal DNA coming in all sizes and shapes

RWK Chiu, YMD Lo - Prenatal Diagnosis, 2021 - Wiley Online Library
Cell‐free fetal DNA analysis has an established role in prenatal assessments. It serves as a
source of fetal genetic material that is accessible non‐invasively from maternal blood …

Maternal‐fetal cross talk through cell‐free fetal DNA, telomere shortening, microchimerism, and inflammation

SB Cheng, S Davis, S Sharma - American Journal of …, 2018 - Wiley Online Library
There exists a strong correlation between unscheduled inflammation at the maternal‐fetal
interface and the continuum of pregnancy complications. In normal pregnancy …

Autoimmune disorders but not heparin are associated with cell-free fetal DNA test failure

Y Dabi, S Guterman, JC Jani, A Letourneau… - Journal of translational …, 2018 - Springer
Background Recent studies have suggested a possible association between heparin
treatment at the time of cell-free DNA (cfDNA) testing and a non-reportable result. However …

Cell-free fetal DNA increases prior to labor at term and in a subset of preterm births

N Gomez-Lopez, R Romero, G Schwenkel… - Reproductive …, 2020 - Springer
Cell-free fetal DNA in the maternal circulation has been associated with the onset of labor at
term. Moreover, clinical studies have suggested that cell-free fetal DNA has value to predict …